2,3-dimethyl-2H-indazol-6-amine hydrochloride

Base Information

• Chemical Name: 2,3-dimethyl-2H-indazol-6-amine hydrochloride
• CAS No.: 635702-60-2
• Molecular Formula: C9H11N3^.HCl
• Molecular Weight: 197.667
• Hs Code.: 2933990090
• Mol file: 635702-60-2.mol

Synonyms:2H-Indazol-6-amine, 2,3-dimethyl-, monohydrochloride (9CI);2,3-Dimethyl-6-amino-2H-indazole hydrochloride;2,3-Dimethyl-2H-indazol-6-amine monohydrochloride;

Chemical Property of 2,3-dimethyl-2H-indazol-6-amine hydrochloride

Chemical Property:

• PSA: 43.84000
• LogP: 2.84710
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2,3-Dimethyl-2H-indazol-6-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-dimethyl-2H-indazol-6-amine hydrochloride

There total 4 articles about 2,3-dimethyl-2H-indazol-6-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,3?dimethyl?6?nitro?2H?indazole (444731-73-1) → 2,3-dimethyl-2H-indazole-6-amine hydrochloride (635702-60-2)

Guidance literature:

With hydrogenchloride; tin(ll) chloride; In diethylene glycol dimethyl ether; water; at 0 ℃; for 0.583333h;

Reference yield:

3-methyl-6-nitro-1H-indazole (6494-19-5) → 2,3-dimethyl-2H-indazole-6-amine hydrochloride (635702-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / -30 - 0 °C

1.2: 17.25 h / -70 - 20 °C

2.1: hydrogenchloride; tin(ll) chloride / diethylene glycol dimethyl ether; water / 0.58 h / 0 °C

With hydrogenchloride; boron trifluoride diethyl etherate; tin(ll) chloride; In dichloromethane; diethylene glycol dimethyl ether; water;

Reference yield:

3-methyl-6-nitro-1H-indazole sulfate (635702-59-9) → 2,3-dimethyl-2H-indazole-6-amine hydrochloride (635702-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane; dimethyl sulfoxide / 7 h / 25 - 70 °C / Heating / reflux

1.2: 20 °C

2.1: hydrogenchloride; tin(ll) chloride / diethylene glycol dimethyl ether; water / 0.58 h / 0 °C

With hydrogenchloride; tin(ll) chloride; In dichloromethane; diethylene glycol dimethyl ether; water; dimethyl sulfoxide;

upstream raw materials:

2,3?dimethyl?6?nitro?2H?indazole

3-methyl-6-nitro-1H-indazole

3-methyl-6-nitro-1H-indazole sulfate

2-ethyl-5-nitroaniline

Downstream raw materials:

N2,N4-bis(2,3-dimethyl-2H-indazol-6-yl)-pyrimidine-2,4-diamine

N-(2-chloropyrimidin-4-yl)-2,3-dimethyl-2H-indazol-6-amine

Refernces

• 1、 -. "Pyrimidineamines as angiogenesis modulators". Paragraph 0178 - 0180. . Retrieved 2015/11/16.
• 2、 -. "Treatment Method". Page/Page column 8-9. . Retrieved 2009/01/20.