4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine

Base Information

Chemical Name:4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine
CAS No.:693228-63-6
Deprecated CAS:1067881-58-6
Molecular Formula:C₁₈H₂₀N₆OS
Molecular Weight:368.462
Hs Code.:
UNII:YAX4981K2D
Nikkaji Number:J2.869.745G
Pharos Ligand ID:H1Z2DWLBQDNR
ChEMBL ID:CHEMBL482967
Mol file:693228-63-6.mol

Synonyms:4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine;CYC 116;CYC-116;CYC116

Suppliers and Price of 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
CYC-116
5mg
$ 496.00

DC Chemicals
CYC116 >98%
100 mg
$ 300.00

Crysdot
CYC-116 98+%
100mg
$ 552.00

Crysdot
CYC-116 98+%
50mg
$ 313.00

ChemScene
CYC-116 98.17%
100mg
$ 582.00

ChemScene
CYC-116 98.17%
10mg
$ 96.00

ChemScene
CYC-116 98.17%
50mg
$ 355.00

Chemenu
4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine 98%
100mg
$ 318.00

Cayman Chemical
CYC-116 ≥98%
25mg
$ 169.00

Cayman Chemical
CYC-116 ≥98%
10mg
$ 82.00

Total 56 raw suppliers

Chemical Property of 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine

Chemical Property:

PSA：118.16000
Density:1.355
LogP:3.13900
Storage Temp.:Hygroscopic, Refrigerator, under inert atmosphere
Solubility.:Aqueous Acid, DMSO (Sparingly)
Water Solubility.:Unknown
XLogP3:2.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:368.14193046
Heavy Atom Count:26
Complexity:443

Purity/Quality:

99%, ^*data from raw suppliers

CYC-116 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4
Recent ClinicalTrials:A Phase I Pharmacologic Study of CYC116, an Oral Aurora Kinase Inhibitor, in Patients With Advanced Solid Tumors
Uses CYC116 is a potent inhibitor of Aurora A/B and VEGFR with Ki of 8.0 nM/9.2 nM and 44 nM, respectively.

Technology Process of 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine

There total 3 articles about 4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 314268-63-8
N,N-(4-morpholin-4-yl-phenyl)-guanidine nitrate

: N'-[5-(3-dimethylamino-acryloyl)-4-methyl-thiazol-2-yl]-N,N-dimethyl-formamidine

: 693228-63-6
[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-morpholin-4-yl-phenyl)-amine

Guidance literature:

Reference yield:

: 507487-90-3
N'-(5-(3-(dimethylamino)acryloyl)-4-methylthiazol-2-yl)-N,N-dimethylformimid amide

: 314268-63-8
N,N-(4-morpholin-4-yl-phenyl)-guanidine nitrate

: 693228-63-6
[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-morpholin-4-yl-phenyl)-amine

Guidance literature:

Reference yield:

: 507487-90-3
N'-(5-(3-(dimethylamino)acryloyl)-4-methylthiazol-2-yl)-N,N-dimethylformimid amide

: 2524-67-6,86759-37-7
4-morpholino-4-yl-phenylamine

: 420-04-2
CYANAMID

: 693228-63-6
[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-morpholin-4-yl-phenyl)-amine

Guidance literature:: 4-morpholino-4-yl-phenylamine; CYANAMID; In ethanol; water; Heating; Acidic conditions;

N'-(5-(3-(dimethylamino)acryloyl)-4-methylthiazol-2-yl)-N,N-dimethylformimid amide; With sodium hydroxide; In ethyl methyl ether; at 125 ℃; for 22h; Inert atmosphere;
DOI:10.1021/jm901913s