(6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: (6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 54752-16-8
• Molecular Formula: C₂₀H₁₉Cl₃N₂O₅S
• Molecular Weight: 505.806

Synonyms:

Chemical Property of (6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

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Useful:

Technology Process of (6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester

There total 3 articles about (6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide (33213-50-2) → (6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester (54752-16-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 0 °C

2: PCl₃

With sodium hydride; phosphorus trichloride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)96234-3

Reference yield:

(6'R)-3'-methyl-5'ξ,8'-dioxo-7't-(2-phenoxy-acetylamino)-(6'rH)-5'λ4-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester (49823-73-6,54774-29-7) → (6'R)-8'-oxo-3'-methyl-7't-(2-phenoxy-acetylamino)-(6'rH)-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester (54752-16-8)

Guidance literature:

With phosphorus trichloride;

DOI:10.1016/S0040-4039(01)96234-3

Reference yield:

→ C20H19Cl3N2O5S (54752-16-8)

Guidance literature:

PCl3, 2,2,2-Trichlorethyl-3-methyl-7-(2-phenoxyacetamido)-2-spirocyclopropyl-3-cephem-4-carboxylat sulfoxid;

upstream raw materials:

(6'R)-3'-methyl-5'ξ,8'-dioxo-7't-(2-phenoxy-acetylamino)-(6'rH)-5'λ⁴-spiro[cyclopropane-1,4'-(5-thia-1-aza-bicyclo[4.2.0]oct-2-ene)]-2'-carboxylic acid 2,2,2-trichloro-ethyl ester

2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

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