N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Base Information

Chemical Name:N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
CAS No.:315703-52-7
Molecular Formula:C₁₉H₁₈N₄OS
Molecular Weight:350.444
Hs Code.:
European Community (EC) Number:683-690-1
DSSTox Substance ID:DTXSID70360042
Nikkaji Number:J3.401.042K
Wikidata:Q72471953
ChEMBL ID:CHEMBL514622
Mol file:315703-52-7.mol

Synonyms:JK184

Suppliers and Price of N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
JK 184
1mg
$ 323.00

Usbiological
JK 184
10mg
$ 438.00

TRC
JK184
100mg
$ 400.00

TRC
JK184
50mg
$ 250.00

Tocris
JK184 ≥99%(HPLC)
25
$ 288.00

Tocris
JK184 ≥99%(HPLC)
5
$ 76.00

Sigma-Aldrich
JK184 ≥98% (HPLC), powder
5mg
$ 76.60

Sigma-Aldrich
Hh Signaling Antagonist VII, JK184
5mg
$ 118.00

Sigma-Aldrich
JK184 ≥98% (HPLC), powder
25mg
$ 296.00

Matrix Scientific
N-(4-Ethoxyphenyl)-4-(2-methylimidazo-[1,2-a]pyridin-3-yl)thiazol-2-amine 95+%
1g
$ 4725.00

Total 24 raw suppliers

Chemical Property of N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Chemical Property:

PSA：79.69000
Density:1.3
LogP:4.98150
Storage Temp.:Store at +4°C
Solubility.:DMSO: ≥20mg/mL
Water Solubility.:soluble to 100 mM in DMSO and to 25 mM in ethanol
XLogP3:5.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:350.12013238
Heavy Atom Count:25
Complexity:432

Purity/Quality:

99%, ^*data from raw suppliers

JK 184 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
Uses JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical] JK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.

Technology Process of N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

There total 3 articles about N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%