D-Myo-inositol-1,4,5-triphosphate (aMMoniuM salt)

Base Information

• Chemical Name: D-Myo-inositol-1,4,5-triphosphate (aMMoniuM salt)
• CAS No.: 345958-55-6
• Molecular Formula: C₆H₁₅O₁₅P₃*6H₃N
• Molecular Weight: 522.28
• Mol file: 345958-55-6.mol

Synonyms:

Chemical Property of D-Myo-inositol-1,4,5-triphosphate (aMMoniuM salt)

Chemical Property:

Purity/Quality:

>99% ^*data from raw suppliers

D-Myo-inositol 1,4,5-triphosphate ammonium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states.

Technology Process of D-Myo-inositol-1,4,5-triphosphate (aMMoniuM salt)

There total 21 articles about D-Myo-inositol-1,4,5-triphosphate (aMMoniuM salt) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-myo-inositol (87-89-8) → D-myo-inositol 1,3,4-triphosphate (112571-68-3,112571-69-4,116183-54-1,127910-79-6,127910-80-9,129704-99-0,129828-70-2,141611-09-8,345958-55-6)

Guidance literature:

Multi-step reaction with 11 steps

1: p-toluenesulfonic acid

2: 94 percent / sodium hydride / dimethylformamide

3: 66 percent / I₂, / methanol

4: 86 percent / sodium hydride / dimethylformamide / 2 h / 60 °C

5: 0.1 M hydrogen chloride / methanol

6: 81 percent / dibutyltinoxide

7: 97 percent / sodium hydride / dimethylformamide / 2 h / 60 °C

8: 86 percent / DDQ

9: 80 percent / 0.1 M hydrogen chloride / methanol

10: 70 percent / butyllithium

11: hydrogen / 5 percent Pd/C / 24 h / Ambient temperature

With hydrogenchloride; n-butyllithium; hydrogen; iodine; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1246/cl.1988.77

Reference yield:

(+/-)-1,2:5,6-dicyclohexylidene-myo-inositol (6763-49-1,23393-19-3,33021-17-9,34361-61-0,34395-04-5,34711-26-7,40773-57-7,41545-19-1,54712-58-2,57089-24-4,57089-25-5,68738-25-0,81601-23-2,120710-65-8,141506-87-8) → D-myo-inositol 1,3,4-triphosphate (112571-68-3,112571-69-4,116183-54-1,127910-79-6,127910-80-9,129704-99-0,129828-70-2,141611-09-8,345958-55-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 94 percent / sodium hydride / dimethylformamide

2: 66 percent / I₂, / methanol

3: 86 percent / sodium hydride / dimethylformamide / 2 h / 60 °C

4: 0.1 M hydrogen chloride / methanol

5: 81 percent / dibutyltinoxide

6: 97 percent / sodium hydride / dimethylformamide / 2 h / 60 °C

7: 86 percent / DDQ

8: 80 percent / 0.1 M hydrogen chloride / methanol

9: 70 percent / butyllithium

10: hydrogen / 5 percent Pd/C / 24 h / Ambient temperature

With hydrogenchloride; n-butyllithium; hydrogen; iodine; sodium hydride; di(n-butyl)tin oxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1246/cl.1988.77

Reference yield:

(±)-1,2:3,4-di-O-cyclohexylidene-myo-inositol (6763-49-1,23393-19-3,33021-17-9,34361-61-0,34395-04-5,34711-26-7,40773-57-7,41545-19-1,54712-58-2,57089-24-4,57089-25-5,68738-25-0,81601-23-2,120710-65-8,141506-87-8) → D-myo-inositol 1,3,4-triphosphate (112571-68-3,112571-69-4,116183-54-1,127910-79-6,127910-80-9,129704-99-0,129828-70-2,141611-09-8,345958-55-6)

Guidance literature:

Multi-step reaction with 10 steps

1: 98 percent / sodium hydride / dimethylformamide / 2 h / 60 °C

2: 60 percent / ethylene glycol, p-toluenesulfonic acid / CHCl₃ / Ambient temperature

3: 93 percent / sodium hydride / dimethylformamide

4: 0.1 M hydrogen chloride / methanol

5: 81 percent / dibutyltinoxide

6: 97 percent / sodium hydride / dimethylformamide / 2 h / 60 °C

7: 86 percent / DDQ

8: 80 percent / 0.1 M hydrogen chloride / methanol

9: 70 percent / butyllithium

10: hydrogen / 5 percent Pd/C / 24 h / Ambient temperature

With hydrogenchloride; n-butyllithium; hydrogen; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid; ethylene glycol; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1246/cl.1988.77

upstream raw materials:

1L-1,2,4-tri-O-benzyl-3,5,6-tris-O-dianilinophosphoryl-myo-inositol

D-myo-inositol

2,3,6-tris-O-(phenylmethyl)-D-myo-inositol

rac-1,2-O-cyclohexylidene-myo-inositol

Refernces

• 1、 Ozaki, Shoichiro,Kohno, Masayasu,Nakahira, Hiroyuki,Bunya, Motonobu,Watanabe, Yutaka. "Synthesis of Optically Active myo-Inositol 1,3,4-Triphosphate". . p. 77 - 80. Retrieved 2007/10/02.