Technology Process of N-(3-cyano-4-neopentyloxyphenyl)-1-methyl-5-phenylpyrazole-3-carboxyamide
There total 8 articles about N-(3-cyano-4-neopentyloxyphenyl)-1-methyl-5-phenylpyrazole-3-carboxyamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethylphosphoryl cyanide; triethylamine;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / DMF (N,N-dimethyl-formamide); toluene / 3 h / 20 °C / Heating / reflux
1.2: Ice cooling
2.1: benzenesulfonyl chloride / DMF (N,N-dimethyl-formamide); toluene / 3 h / 20 - 145 °C
3.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 1 h / Ice cooling
4.1: iron; ammonium chloride / ethanol; water / 0.83 h / 65 °C / Heating / reflux
5.1: diethylphosphoryl cyanide; triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C
With
thionyl chloride; diethylphosphoryl cyanide; iron; sodium hydride; ammonium chloride; triethylamine; benzenesulfonyl chloride;
In
DMF (N,N-dimethyl-formamide); ethanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydroxide / ethanol; water / 0.5 h / Heating / reflux
2: diethylphosphoryl cyanide; triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / 20 °C
With
sodium hydroxide; diethylphosphoryl cyanide; triethylamine;
In
DMF (N,N-dimethyl-formamide); ethanol; water;