1H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid, 2,3,4,7-tetrahydro-1,3-dimethyl-2,4-dioxo-, methyl ester

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid, 2,3,4,7-tetrahydro-1,3-dimethyl-2,4-dioxo-, methyl ester
• CAS No.: 119350-50-4
• Molecular Formula: C₁₀H₁₁N₃O₄
• Molecular Weight: 237.215
• Mol file: 119350-50-4.mol

Synonyms:

Chemical Property of 1H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid, 2,3,4,7-tetrahydro-1,3-dimethyl-2,4-dioxo-, methyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid, 2,3,4,7-tetrahydro-1,3-dimethyl-2,4-dioxo-, methyl ester

There total 2 articles about 1H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid, 2,3,4,7-tetrahydro-1,3-dimethyl-2,4-dioxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

sodium methylate (124-41-4) + 6-trichloroacetyl-1,3-dimethylpyrrolo<2,3-d>pyrimidine-2,4-dione (107266-23-9) → methyl 1,3-dimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (119350-50-4)

Guidance literature:

In methanol; for 15h; Ambient temperature;

DOI:10.1002/jhet.5570250536

Reference yield:

1,3-Dimethylpyrrolo<2,3-d>pyrimidine-2,4-dione (39112-72-6) → methyl 1,3-dimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (119350-50-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / trifluoroacetic acid / 48 h / 50 °C

2: 78 percent / methanol / 15 h / Ambient temperature

With trifluoroacetic acid; In methanol;

DOI:10.1002/jhet.5570250536

Reference yield:

methyl 1,3-dimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (119350-50-4) → C20H22N4O5

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C

2: bromine / chloroform / 50 °C

3: methanol / Reflux

4: methanol / 5 h / Reflux

With bromine; potassium carbonate; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1111/cbdd.13975

upstream raw materials:

sodium methylate

6-trichloroacetyl-1,3-dimethylpyrrolo<2,3-d>pyrimidine-2,4-dione

1,3-Dimethylpyrrolo<2,3-d>pyrimidine-2,4-dione

Downstream raw materials:

7-{2-hydroxy-3-[(4-methylphenyl)sulfanyl]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

1,3-dimethyl-8-[(4-methylphenylsulfanyl)methyl]-8,9-dihydro-2H-pyrimido[5',4':4,5]pyrrolo[2,1-c]-[1,4]oxazino-2,4,6(1H,3H)-trione

1,3-dimethyl-8-[(4-chlorophenylsulfanyl)methyl]-8,9-dihydro-2H-pyrimido[5',4':4,5]pyrrolo[2,1-c]-[1,4]oxazino-2,4,6(1H,3H)-trione

Refernces