7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Base Information

• Chemical Name: 7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
• CAS No.: 1391712-70-1
• Molecular Formula: C₁₉H₂₁ClN₄O₄S
• Molecular Weight: 436.919
• Mol file: 1391712-70-1.mol

Synonyms:

Chemical Property of 7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

There total 3 articles about 7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,3-dimethyl-8-[(4-chlorophenylsulfanyl)methyl]-8,9-dihydro-2H-pyrimido[5',4':4,5]pyrrolo[2,1-c]-[1,4]oxazino-2,4,6(1H,3H)-trione (1391712-72-3) + methylamine (74-89-5) → 7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1391712-70-1)

Guidance literature:

With methanol; for 3h; Reflux;

DOI:10.1007/s10593-012-1019-x

Reference yield:

methyl 1,3-Dimethyl-2,4-dioxo-7-(prop-2-en-1-yl)-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (1391712-61-0) → 7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1391712-70-1)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / chloroform / 50 °C

2: triethylamine / acetonitrile / 2 h / Reflux

3: methanol / 3 h / Reflux

With methanol; bromine; triethylamine; In chloroform; acetonitrile;

DOI:10.1007/s10593-012-1019-x

Reference yield:

methyl 1,3-dimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (119350-50-4) → 7-{-3-[(4-chlorophenyl)sulfanyl-2-hydroxy]propyl}-N,1,3-trimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1391712-70-1)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 75 °C

2: bromine / chloroform / 50 °C

3: triethylamine / acetonitrile / 2 h / Reflux

4: methanol / 3 h / Reflux

With methanol; bromine; potassium carbonate; triethylamine; In chloroform; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1007/s10593-012-1019-x

upstream raw materials:

methyl 1,3-dimethyl-2,4-dioxo-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate

1,3-dimethyl-8-[(4-chlorophenylsulfanyl)methyl]-8,9-dihydro-2H-pyrimido[5',4':4,5]pyrrolo[2,1-c]-[1,4]oxazino-2,4,6(1H,3H)-trione

methylamine

methyl 1,3-Dimethyl-2,4-dioxo-7-(prop-2-en-1-yl)-2,3,4,7-tetrahydro-1H-pyrrolo[2,3-d]pyrimidine-6-carboxylate