METHYL 4-METHOXY-5-AZAINDOLE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 4-METHOXY-5-AZAINDOLE-2-CARBOXYLATE
• CAS No.: 871583-16-3
• Molecular Formula: C₁₀H₁₀N₂O₃
• Molecular Weight: 206.201
• Hs Code.: 2933990090
• Mol file: 871583-16-3.mol

Synonyms:1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid, 4-methoxy-, methyl ester;4-Methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid methyl ester;Methyl 4-methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylate;Methyl-4-methoxy-1H-pyrrolo[3,2-c]pyridin-2-carboxylat;

Chemical Property of METHYL 4-METHOXY-5-AZAINDOLE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 172-174 °C (decomp)
• Refractive Index: 1.619
• Boiling Point: 375.189 °C at 760 mmHg
• PKA: 13.39±0.40(Predicted)
• Flash Point: 180.708 °C
• PSA: 64.21000
• Density: 1.313 g/cm³
• LogP: 1.35810
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-METHOXY-5-AZAINDOLE-2-CARBOXYLATE

There total 4 articles about METHYL 4-METHOXY-5-AZAINDOLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl (2Z)-2-azido-3-(2-methoxypyridin-3-yl)prop-2-enoate → methyl 4-methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (871583-16-3)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 2h;

DOI:10.1002/hlca.202100211

Reference yield: 93.0%

C10H10N4O3 → methyl 4-methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (871583-16-3)

Guidance literature:

In 1,3,5-trimethyl-benzene; at 160 ℃;

DOI:10.15227/orgsyn.084.0262

Reference yield:

2-methoxynicotinaldehyde (71255-09-9) → methyl 4-methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylate (871583-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / NaOMe / methanol / -10 - 0 °C

2: 93 percent / 1,3,5-trimethyl-benzene / 1 h / Heating

With sodium methylate; In methanol; 1,3,5-trimethyl-benzene; 2: Hemetsberger-Knittel reaction;

DOI:10.1055/s-2005-872165

upstream raw materials:

2-methoxynicotinaldehyde

2-methoxypyridine

Downstream raw materials:

4-methoxy-1H-pyrrolo[3,2-c]pyridine

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