4-METHOXY-5-AZAINDOLE

Base Information

• Chemical Name: 4-METHOXY-5-AZAINDOLE
• CAS No.: 944900-76-9
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Hs Code.: 2933990090
• Mol file: 944900-76-9.mol

Synonyms:4-methoxy-1H-pyrrolo[3,2-c]pyridine;

Chemical Property of 4-METHOXY-5-AZAINDOLE

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 90-91°
• Boiling Point: 304.145°C at 760 mmHg
• PKA: 15.42±0.40(Predicted)
• Flash Point: 104.512°C
• PSA: 37.91000
• Density: 1.244g/cm³
• LogP: 1.57150
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-methoxy-1H-pyrrolo[3,2-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-5-AZAINDOLE

There total 7 articles about 4-METHOXY-5-AZAINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

sodium methylate (124-41-4) + 4-chloro-1H-pyrrolo-[3,2-c]-pyridine (60290-21-3) → 4-methoxy-1H-pyrrolo[3,2-c]pyridine (944900-76-9)

Guidance literature:

In methanol; at 120 ℃; for 16h; Sealed tube;

Reference yield: 49.0%

C9H8N2O3*ClH → 4-methoxy-1H-pyrrolo[3,2-c]pyridine (944900-76-9)

Guidance literature:

With copper; In 1-methyl-pyrrolidin-2-one; at 205 ℃; for 19h; Inert atmosphere;

DOI:10.1002/hlca.202100211

Reference yield: 30.0%

methanol (67-56-1) + 4-chloro-1H-pyrrolo-[3,2-c]-pyridine (60290-21-3) → 4-methoxy-1H-pyrrolo[3,2-c]pyridine (944900-76-9)

Guidance literature:

With sodium; at 0 - 120 ℃; for 36h; Inert atmosphere; Sealed tube;

DOI:10.1002/hlca.202100211

upstream raw materials:

sodium methylate

4-chloro-1H-pyrrolo-[3,2-c]-pyridine

methyl 4-methoxy-1H-pyrrolo[3,2-c]pyridine-2-carboxylate

2-methoxynicotinaldehyde

Refernces

• 1、 -. "BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS". Paragraph 0250; 0488. . Retrieved 2020/10/21.