tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate
• CAS No.: 162045-53-6
• Molecular Formula: C₁₇H₂₂N₂O₄
• Molecular Weight: 318.373
• Hs Code.: 2934999090
• Mol file: 162045-53-6.mol

Synonyms:1,1-Dimethylethyl4-(2-oxo-1,3-benzoxazol-3(2H)-yl)piperidine-1-carboxylate; 4-(2-Oxobenzoxazol-3-yl)piperidine-1-carboxylicacid tert-butyl ester

Chemical Property of tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 435.6oC at 760 mmHg
• Flash Point: 217.244oC
• PSA: 64.68000
• Density: 1.246g/cm3
• LogP: 3.10440

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate

There total 8 articles about tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-(1-benzylpiperidin-4-yl)benzo[d]oxazole-2(3H)-one → tert-butyl-4-(2-oxobenzo[d]oxazole-3-(2H)-yl)piperidin-1-carboxylate (162045-53-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 20 ℃; for 2h;

DOI:10.1002/cmdc.201700234

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 2-amino-phenol (95-55-6) → tert-butyl-4-(2-oxobenzo[d]oxazole-3-(2H)-yl)piperidin-1-carboxylate (162045-53-6)

Guidance literature:

With NaBH(OAc)3; In dichloromethane;

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 1-(tert-butoxycarbonyl)-4-[(2-hydroxyphenyl)amino]piperidine (162045-48-9) → tert-butyl-4-(2-oxobenzo[d]oxazole-3-(2H)-yl)piperidin-1-carboxylate (162045-53-6)

Guidance literature:

DOI:10.1016/S0960-894X(98)00446-6

upstream raw materials:

bis(trichloromethyl) carbonate

1-(tert-butoxycarbonyl)-4-[(2-hydroxyphenyl)amino]piperidine

N-tert-butyloxycarbonylpiperidin-4-one

2-amino-phenol

Downstream raw materials:

5-Chloro-1,1-dioxido-2-(4-(4-(2-oxo-3-benzoxazolinyl)-piperidin-1-yl)-butyl)-1,2-benzisothiazol-3(2H)-one

4-[2(3H)-oxobenzoxazol-3-yl]piperidine