1-BOC-4-[(2-HYDROXYPHENYL)AMINO]-PIPERIDINE

Base Information

• Chemical Name: 1-BOC-4-[(2-HYDROXYPHENYL)AMINO]-PIPERIDINE
• CAS No.: 162045-48-9
• Molecular Formula: C16H24 N2 O3
• Molecular Weight: 292.378
• Hs Code.: 2933399090
• Mol file: 162045-48-9.mol

Synonyms:4-(2-Hydroxyphenylamino)piperidine-1-carboxylicacid tert-butyl ester

Chemical Property of 1-BOC-4-[(2-HYDROXYPHENYL)AMINO]-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 429.801oC at 760 mmHg
• Flash Point: 213.736oC
• PSA: 61.80000
• Density: 1.179g/cm3
• LogP: 3.21450

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-((2-hydroxyphenyl)amino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-[(2-HYDROXYPHENYL)AMINO]-PIPERIDINE

There total 6 articles about 1-BOC-4-[(2-HYDROXYPHENYL)AMINO]-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 2-amino-phenol (95-55-6) → 1-(tert-butoxycarbonyl)-4-[(2-hydroxyphenyl)amino]piperidine (162045-48-9)

Guidance literature:

Reference yield: 45.0%

EtOAc-hexanes + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 2-amino-phenol (95-55-6) → 1-(tert-butoxycarbonyl)-4-[(2-hydroxyphenyl)amino]piperidine (162045-48-9)

Guidance literature:

With NaCNBH₃; acetic acid; In ethyl acetate; toluene;

Reference yield:

glacial HOAc + ? molecular sieves + conc. NH4 OH + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 2-amino-phenol (95-55-6) → 1-(tert-butoxycarbonyl)-4-[(2-hydroxyphenyl)amino]piperidine (162045-48-9)

Guidance literature:

With NaBH(OAc)3; In methanol; dichloromethane; 1,2-dichloro-ethane;

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

2-amino-phenol

1,2-dichloro-ethane

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl-4-(2-oxobenzo[d]oxazole-3-(2H)-yl)piperidin-1-carboxylate

4-[2(3H)-oxobenzoxazol-3-yl]piperidine

5-Chloro-1,1-dioxido-2-(4-(4-(2-oxo-3-benzoxazolinyl)-piperidin-1-yl)-butyl)-1,2-benzisothiazol-3(2H)-one

1-(Tert-Butoxycarbonyl)-4-[(2-methoxycarbonylmethoxyphenyl)amino]piperidine