1,3-Dihydro-5-nitro-3-spirocyclohexaneindol-2-one

Base Information

• Chemical Name: 1,3-Dihydro-5-nitro-3-spirocyclohexaneindol-2-one
• CAS No.: 156232-54-1
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 246.266
• Mol file: 156232-54-1.mol

Synonyms:1,3-Dihydro-5-nitro-3-spirocyclohexaneindol-2-one

Chemical Property of 1,3-Dihydro-5-nitro-3-spirocyclohexaneindol-2-one

Chemical Property:

• Boiling Point: 465.4±45.0 °C(Predicted)
• PKA: 12.43±0.20(Predicted)
• PSA: 78.41000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 3.35710
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5'-Nitrospiro[cyclohexane-1,3'-indolin]-2'-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3-Dihydro-5-nitro-3-spirocyclohexaneindol-2-one

There total 4 articles about 1,3-Dihydro-5-nitro-3-spirocyclohexaneindol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

spiro[cyclohexane-1,3'-[3H]indol]-2'(1'H)-one (4933-14-6) → 5'-nitrospiro[cyclohexane-1,3'-indoline]-2'-one (156232-54-1)

Guidance literature:

With sulfuric acid; nitric acid; at -20 - 20 ℃; for 2h;

Reference yield:

2-oxoindole (59-48-3) → 5'-nitrospiro[cyclohexane-1,3'-indoline]-2'-one (156232-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 - -50 °C

1.2: 7 h / 20 °C / Reflux

2.1: sulfuric acid; nitric acid / 2 h / -20 - 20 °C

With sulfuric acid; nitric acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;

Reference yield:

1,5-dibromo-pentane (111-24-0) → 5'-nitrospiro[cyclohexane-1,3'-indoline]-2'-one (156232-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; hexane / 0.5 h / -78 - -50 °C

1.2: 7 h / 20 °C / Reflux

2.1: sulfuric acid; nitric acid / 2 h / -20 - 20 °C

With sulfuric acid; nitric acid; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;

upstream raw materials:

2-oxoindole

1,5-dibromo-pentane

spiro[cyclohexane-1,3'-[3H]indol]-2'(1'H)-one

Refernces