4933-14-6

Basic information

• Product Name: SPIRO[CYCLOHEXANE-1,3'-[3H]INDOL]-2'(1'H)-ONE
• Synonyms: SPIRO[CYCLOHEXANE-1,3'-[3H]INDOL]-2'(1'H)-ONE;spiro[cyclohexane-1,3'-indolin]-2'-one;1',3'-dihydrospiro[cyclohexane-1,3'-(2'H)-indole]-2'-one
• CAS NO: 4933-14-6
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.26
• Mol File: 4933-14-6.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SPIRO[CYCLOHEXANE-1,3'-[3H]INDOL]-2'(1'H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[CYCLOHEXANE-1,3'-[3H]INDOL]-2'(1'H)-ONE(4933-14-6)
• EPA Substance Registry System: SPIRO[CYCLOHEXANE-1,3'-[3H]INDOL]-2'(1'H)-ONE(4933-14-6)

Safety Data

• Hazardous Substances Data: 4933-14-6(Hazardous Substances Data)

Upstream product

• 68557-32-4 cyclohexanecarboxylic acid N'-phenylhydrazide 
• 87967-38-2 1-anilinocyclohexanecarboxylic acid 
• 628-77-3 1,5-diiodopentane 
• 109686-66-0 Cyclohex-1-enecarboxylic acid (2-bromo-phenyl)-(2-trimethylsilanyl-ethoxymethyl)-amide 
• 59-48-3 2-oxoindole 
• 111-24-0 1,5-dibromo-pentane 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 106795-58-8 (o-fluorobenzyl)triphenylphosphonium chloride 
• 106795-74-8 1-(2-bromophenyl)cyclohexane-1-carbonitrile 
• 106795-73-7 1-(2-chlorophenyl)cyclohexane-1-carbonitrile 
• 106795-72-6 1-(2-fluorophenyl)cyclohexane-1-carbonitrile 
• 345-35-7 2-fluorobenzyl chloride 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 326-62-5 2-fluorophenyl acetonitrile 

Downstream Products

• 304468-42-6 5'-bromospiro[cyclohexane-1,3'-[3H]indol]-2'(1'H)-one 
• 929564-62-5 1'-(3-fluorobenzyl)spiro[cyclohexane-1,3'-indol]-2'(1'H)-one 
• 929564-55-6 1'-[3-(tert-butoxycarbonyl-methylamino)-1-phenylpropyl]spiro[cyclohexane-1,3'-indol]-2'(1'H)-one 
• 870072-66-5 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] 
• 870072-67-6 1′-(2-nitrophenyl)spiro[cyclohexane-1,3′-indoline] 
• 304875-03-4 3-(1',2'-dihydro-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)-5-fluorobenzonitrile 
• 304875-02-3 3-(1',2'-Dihydro-2'-oxospiro[cyclohexane-1,3'-[3H]indol]-5'-yl)benzonitrile 
• 304874-75-7 5'-(3-chlorophenyl)spiro[cyclohexane-1,3'-[3H]indole]-2'(1'H)-one 

Relevant articles and documents

Synthesis of 3,3-disubstituted oxindoles

A novel and efficient two-step synthetic sequence for the preparation of 3,3-disubstituted oxindoles was developed starting from arylhydrazines and α-branched aldehydes via Fischer indole type synthesis followed by imine oxidation.

Efficient copper-catalyzed intramolecular N-arylation for the synthesis of oxindoles

An efficient copper-catalyzed intramolecular N-arylation was performed by using substituted 2-(2-bromoaryl)acetamide with a small amount of Cu 2O and benzene-1,2-diamine as catalytic system under aerobic conditions, which provided good to excellent yields of oxindoles with tolerance of a wide variety of substrates.

Copper-catalyzed domino coupling reaction: An efficient method to synthesize oxindoles

An efficient and novel procedure for a copper catalyzed domino coupling reaction has been developed, which afforded various oxindoles in good to excellent yields with tolerance of various substituents. In addition, this method could be applied to synthesize horsfiline and coerulescine in few steps with high total yields. The Royal Society of Chemistry 2012.