5-(2,5-dioxopyrrolidin-1-yl) 1-methyl palmitoyl-L-glutamate

Base Information

• Chemical Name: 5-(2,5-dioxopyrrolidin-1-yl) 1-methyl palmitoyl-L-glutamate
• CAS No.: 294855-90-6
• Molecular Formula: C₂₆H₄₄N₂O₇
• Molecular Weight: 496.645
• Mol file: 294855-90-6.mol

Synonyms:

Chemical Property of 5-(2,5-dioxopyrrolidin-1-yl) 1-methyl palmitoyl-L-glutamate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2,5-dioxopyrrolidin-1-yl) 1-methyl palmitoyl-L-glutamate

There total 4 articles about 5-(2,5-dioxopyrrolidin-1-yl) 1-methyl palmitoyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-Hexadecanoyl-L-glutamic acid α-methyl ester (73793-91-6) → 5-(2,5-dioxopyrrolidin-1-yl)-1-methylpalmitoyl L-glutamate (294855-90-6)

Guidance literature:

N-Hexadecanoyl-L-glutamic acid α-methyl ester; With diisopropyl-carbodiimide; In tetrahydrofuran; at 20 - 30 ℃; for 0.25h;

1-hydroxy-pyrrolidine-2,5-dione; In tetrahydrofuran; at 20 - 30 ℃;

Reference yield:

1-hexadecylcarboxylic acid (57-10-3) → 5-(2,5-dioxopyrrolidin-1-yl)-1-methylpalmitoyl L-glutamate (294855-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3.1: diisopropyl-carbodiimide / tetrahydrofuran / 0.25 h / 20 °C

3.2: 20 °C

With triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane;

Reference yield:

L-glutamic acid 5-tert-butyl ester (2419-56-9) → 5-(2,5-dioxopyrrolidin-1-yl)-1-methylpalmitoyl L-glutamate (294855-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3.1: diisopropyl-carbodiimide / tetrahydrofuran / 0.25 h / 20 °C

3.2: 20 °C

With triethylamine; trifluoroacetic acid; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane;

upstream raw materials:

1-hexadecylcarboxylic acid

L-glutamic acid 5-tert-butyl ester

1-hydroxy-pyrrolidine-2,5-dione

N-Hexadecanoyl-L-glutamic acid α-methyl ester