2419-56-9Relevant articles and documents
Synthesis of ω-tert-butyl esters of aspartic acid and glutamic acid via B,B-difluoroboroxazolidones
Wang, Jidong,Okada, Yoshio,Wang, Zongmu,Wang, Yuhong,Li, Wei
, p. 2189 - 2191 (1996)
B,B-Difluoroboroxazolidones (DFBONs) were synthesized for the first time from salts of amino acid and BF3·Et2O, and their properties were examined. DFBONs were used in selective preparation of Glu(OBu(t)) and Asp(OBu(t)) in good yields under catalysis with BF3·Et2O and H3PO4. Amberlite XAD-2 resin was successfully employed to purify the above amino acid derivatives.
ANTI-CD40 ANTIBODY DRUG CONJUGATES
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Paragraph 00149, (2019/06/17)
Provided herein are anti-CD40 antibody drug conjugates comprising a radical of Formula (I), wherein R1, R2, and R3 are as defined herein. Further provided are anti-CD40 antibody drug conjugates of Formula (II), wherein Z, R, AA1, AA2, AA3, m, p, q, n, w, R1, R2, and R3 are as defined herein. Further provided are pharmaceutical compositions and kits thereof, and methods of using same.
Fluorescent mimics of cholesterol that rapidly bind surfaces of living mammalian cells
Hymel, David,Cai, Sutang,Sun, Qi,Henkhaus, Rebecca S.,Perera, Chamani,Peterson, Blake R.
supporting information, p. 14624 - 14627 (2015/09/28)
Mammalian cells acquire cholesterol, a critical membrane constituent, through multiple mechanisms. We synthesized mimics of cholesterol, fluorescent N-alkyl-3β-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor-mediated uptake pathway.