(2S,3S)-3-ethylaspartic acid

Base Information

• Chemical Name: (2S,3S)-3-ethylaspartic acid
• CAS No.: 7298-97-7
• Molecular Formula: C₆H₁₁NO₄
• Molecular Weight: 161.158
• Mol file: 7298-97-7.mol

Synonyms:

Chemical Property of (2S,3S)-3-ethylaspartic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3S)-3-ethylaspartic acid

There total 8 articles about (2S,3S)-3-ethylaspartic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethylfumaric acid (5469-25-0) → (2S,3S)-3-ethylaspartic acid (7298-97-7,15383-88-7,61521-33-3,61521-34-4)

Guidance literature:

With ammonium hydroxide; 3-methylaspartate ammonia-lyase; sodium chloride; magnesium chloride; at 30 ℃; for 50h;

Reference yield:

diethyl 2-ethylidenesuccinate (141331-33-1) → (2S,3S)-3-ethylaspartic acid (7298-97-7,15383-88-7,61521-33-3,61521-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: DBU / toluene / Heating

1.2: 81 percent / aq. HCl / 3 h / Heating

2.1: 60 percent / β-methyl aspartase; KCl; NH4Cl / MgCl2*6H2O / H2O / 32 °C / pH 9

With β-methyl aspartase; potassium chloride; ammonium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; magnesium chloride; In water; toluene;

DOI:10.1002/ejoc.200300410

Reference yield:

ethyl 2-ethyl-3-oxobutanoate (607-97-6) → (2S,3S)-3-ethylaspartic acid (7298-97-7,15383-88-7,61521-33-3,61521-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Br₂, 2.) KOH / 1.) diethyl ether, reflux, 3 h; 2.) ethanol, reflux, 3 min

2: 60 percent / MgCl₂, KCl, concd. aq. ammonia / 40 h / 30 °C / with 3-methylaspartase

With potassium hydroxide; ammonium hydroxide; potassium chloride; bromine; magnesium chloride;

DOI:10.1016/S0040-4020(01)87795-4

upstream raw materials:

Methyl 2-bromobutyrate

Ethyl isocyanoacetate

methanol

2-ethyl-3-bromo-succinic acid

Downstream raw materials:

L-isoleucine hydrochloride

ethylfumaric acid

Refernces

• 1、 Siebum, Arjan H. G.,Woo, Wei Sein,Lugtenburg, Johan. "Preparation and Characterization of [5-13C]-(2S,4R)-Leucine and [4-13C]-(2S,3S)-Valine - Establishing Synthetic Schemes to Prepare Any Site-Directed Isotopomer of L-Leucine, L-Isoleucine and L-Valine". . p. 4664 - 4678. Retrieved 2007/10/03.
• 2、 -. "Process for the preparation of N-protected dialkyl (2S,3S)-3-ethylaspartates". . . Retrieved 2008/06/13.