N-(2-hydroxyphenyl)butanamide

Base Information

• Chemical Name: N-(2-hydroxyphenyl)butanamide
• CAS No.: 28033-54-7
• Molecular Formula: C10H13 N O2
• Molecular Weight: 179.219
• NSC Number: 86975
• UNII: DHF85H3YHL
• DSSTox Substance ID: DTXSID40182314
• Nikkaji Number: J1.550.088C
• Wikidata: Q83052977
• Mol file: 28033-54-7.mol

Synonyms:N-(2-hydroxyphenyl)butanamide;28033-54-7;Butyranilide, 2'-hydroxy-;NSC 86975;2'-Hydroxybutyranilide;DHF85H3YHL;NSC-86975;butyramidophenol;Aethylacetamidophenol;UNII-DHF85H3YHL;2'-Hydroxy-, butyranilide;NCIOpen2_001199;SCHEMBL5536448;DTXSID40182314;KIUGSVWAFHJWDU-UHFFFAOYSA-N;Butanamide, N-(2-hydroxyphenyl)-;N-(2-Hydroxyphenyl)-, butanamide;NSC86975;MFCD00462980;AKOS002944354;AN-652/11668364

Chemical Property of N-(2-hydroxyphenyl)butanamide

Chemical Property:

• Vapor Pressure: 1.16E-05mmHg at 25°C
• Boiling Point: 359.3°C at 760 mmHg
• Flash Point: 171.1°C
• Density: 1.164g/cm³
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC(=O)NC1=CC=CC=C1O

Technology Process of N-(2-hydroxyphenyl)butanamide

There total 5 articles about N-(2-hydroxyphenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-butyryl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamide + 2-amino-phenol (95-55-6) → N-(4-chlorophenyl)-4-nitrobenzenesulfonamide (16937-03-4) + butyric acid-(2-hydroxy-anilide) (28033-54-7)

Guidance literature:

With potassium carbonate; In water; at 80 ℃; for 2h; chemoselective reaction; Green chemistry;

DOI:10.1515/znb-2015-0076

Reference yield: 49.0%

butanoic acid anhydride (106-31-0) + 2-amino-phenol (95-55-6) → butyric acid-(2-hydroxy-anilide) (28033-54-7)

Guidance literature:

In benzene; for 72h; Ambient temperature;

Reference yield:

1-butyrylamino-2-phenylacetoxy-benzene (857780-26-8) → butyric acid-(2-hydroxy-anilide) (28033-54-7)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja01354a023

upstream raw materials:

1-butyrylamino-2-phenylacetoxy-benzene

butyryl chloride

2-amino-phenol

butanoic acid anhydride

Downstream raw materials:

1-butyrylamino-2-phenylacetoxy-benzene

trifluoro-methanesulfonic acid 2-butyrylamino-phenyl ester

indole

2-propyl-indole