(2S)-2-(phenoxymethyl)pyrrolidine

Base Information

Chemical Name:(2S)-2-(phenoxymethyl)pyrrolidine
CAS No.:174213-76-4
Molecular Formula:C11H15 N O
Molecular Weight:177.246
Hs Code.:
DSSTox Substance ID:DTXSID30431823
Nikkaji Number:J1.255.572E
Wikidata:Q82245807
ChEMBL ID:CHEMBL418900
Mol file:174213-76-4.mol

Synonyms:(2S)-2-(phenoxymethyl)pyrrolidine;174213-76-4;(S)-2-(phenoxymethyl)pyrrolidine;CHEMBL418900;SCHEMBL5332805;(S)-2-Phenoxymethyl-pyrrolidine;DTXSID30431823;CVINTVJDIQIIGZ-JTQLQIEISA-N;(S)-(+)-2-Phenoxymethylpyrrolidine;BDBM50287813;MFCD10022827;AKOS006303822;AS-47677;EN300-159892;F15220

Suppliers and Price of (2S)-2-(phenoxymethyl)pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S)-2-(phenoxymethyl)pyrrolidine
10mg
$ 45.00

Crysdot
(S)-2-(Phenoxymethyl)pyrrolidine 95+%
1g
$ 465.00

Chemenu
(S)-2-(Phenoxymethyl)pyrrolidine 95%
1g
$ 439.00

American Custom Chemicals Corporation
(S)-2-(PHENOXYMETHYL)PYRROLIDINE 95.00%
1G
$ 737.10

American Custom Chemicals Corporation
(S)-2-(PHENOXYMETHYL)PYRROLIDINE 95.00%
5MG
$ 498.67

Alichem
(S)-2-(Phenoxymethyl)pyrrolidine
1g
$ 449.08

Total 4 raw suppliers

Chemical Property of (2S)-2-(phenoxymethyl)pyrrolidine

Chemical Property:

Vapor Pressure:0.00456mmHg at 25°C
Boiling Point:277.3oC at 760 mmHg
Flash Point:109.8oC
PSA：21.26000
Density:1.017g/cm3
LogP:2.14620
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:177.115364102
Heavy Atom Count:13
Complexity:143

Purity/Quality:

99% ^*data from raw suppliers

(2S)-2-(phenoxymethyl)pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(NC1)COC2=CC=CC=C2
Isomeric SMILES:C1C[C@H](NC1)COC2=CC=CC=C2

Technology Process of (2S)-2-(phenoxymethyl)pyrrolidine

There total 11 articles about (2S)-2-(phenoxymethyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: N-benzyl-(S)-2-(phenoxymethyl)pyrrolidine

: 174213-76-4
(S)-2-(phenoxymethyl)-pyrrolidine

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; for 168h;
DOI:10.1055/s-0037-1610770

Reference yield: 79.0%

: 174213-51-5
(S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate

: 174213-76-4
(S)-2-(phenoxymethyl)-pyrrolidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1021/jm0100537

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 174213-76-4
(S)-2-(phenoxymethyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 70 percent / pyridine / CH₂Cl₂ / 16 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

2.2: 78 percent / tetrahydrofuran / 12 h / Heating

3.1: TFA / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm051217c