174213-51-5

Basic information

• Product Name: (S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate
• Synonyms: (S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylicacid, 2-(phenoxymethyl)-, 1,1-dimethylethyl ester, (2S)-
• CAS NO: 174213-51-5
• Molecular Formula: C₁₆H₂₃NO₃
• Molecular Weight: 277.362
• Mol File: 174213-51-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 373.73°C at 760 mmHg
• Flash Point: 179.826°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate(174213-51-5)
• EPA Substance Registry System: (S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate(174213-51-5)

Safety Data

• Hazardous Substances Data: 174213-51-5(Hazardous Substances Data)

Usage

General Description

(S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate is a chemical compound with the molecular formula C15H25NO3. It is a pyrrolidine derivative that contains a tert-butyl group and a phenoxymethyl group. (S)-tert-butyl 2-(phenoxymethyl)pyrrolidine-1-carboxylate is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. Its versatile nature makes it a valuable intermediate in organic synthesis, particularly in the production of drugs and other biologically active compounds. Its unique structure allows it to participate in a wide range of chemical reactions, making it a valuable tool for researchers and chemists in the development of new compounds and materials.

InChI:InChI=1/C16H23NO3/c1-16(2,3)20-15(18)17-11-7-8-13(17)12-19-14-9-5-4-6-10-14/h4-6,9-10,13H,7-8,11-12H2,1-3H3/t13-/m0/s1

Upstream product

• 1198149-98-2 tert-butyl (2S)-2-[(4-iodophenoxy)methyl]pyrrolidine-1-carboxylate 
• 106-48-9 4-chloro-phenol 
• 170491-63-1 N-Boc-prolinol 
• 1972-28-7 diethylazodicarboxylate 
• 108-95-2 phenol 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 86661-32-7 (S)-tert-butyl 2-((tosyloxy)methyl)pyrrolidine-1-carboxylate 

Downstream Products

• 174213-76-4 (S)-2-(phenoxymethyl)-pyrrolidine 
• 220510-31-6 [2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydro-indol-1-yl]-acetic acid tert-butyl ester 
• 872254-18-7 acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester 
• 912942-82-6 methanesulfonic acid (S)-2-{4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydro-indol-1-ylmethyl]-phenoxy}ethyl ester 
• 220509-98-8 5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione 
• 899818-37-2 (S)-1-(p-tert-butyldimethylsilyloxybenzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin 
• 899818-41-8 (S)-1-[4-(2-bromoethoxy)-benzyl]-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione 
• 220510-16-7 (S)-1-benzyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatin 
• 220510-28-1 (S)-1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione 

Relevant articles and documents

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors

ABTRACT: In this paper, a new series of isatin-sulphonamide based derivatives were designed, synthesised and evaluated as caspase inhibitors. The compounds containing 1-(pyrrolidinyl)sulphonyl and 2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl substitution at C5 position of isatin core exhibited better results compared to unsubstituted derivatives. According to the results of caspase inhibitory activity, compound 20d showed moderate inhibitory activity against caspase-3 and ?7 in?vitro compared to Ac-DEVD-CHO (IC50 = 0.016 ± 0.002 μM). Among the studied compounds, some active inhibitors with IC50s in the range of 2.33–116.91 μM were identified. The activity of compound 20d was rationalised by the molecular modelling studies exhibiting the additional van der Waals interaction of N-phenylacetamide substitution along with efficacious T-shaped π-π and pi-cation interactions. The introduction of compound 20d with good caspase inhibitory activity will help researchers to find more potent agents.

AMIDO-THIOPHENE COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit 11 β-hydroxysteroid dehydrogenase type 1 (11 β-HSD1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11 β-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11 β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.

Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18f]fluoroethylazide

Imaging of programmed cell death (apoptosis) is important in the assessment of therapeutic response in oncology and for diagnosis in cardiac and neurodegenerative disorders. The executioner caspases 3 and 7 ultimately effect cellular death, thus providing