2-Amino-5-iodonicotinic acid

Base Information

• Chemical Name: 2-Amino-5-iodonicotinic acid
• CAS No.: 54400-30-5
• Molecular Formula: C6H5IN2O2
• Molecular Weight: 264.02100
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00694766
• Wikidata: Q72438442
• Mol file: 54400-30-5.mol

Synonyms:2-Amino-5-iodonicotinic acid;54400-30-5;2-amino-5-iodopyridine-3-carboxylic acid;2-AMINO-5-IODO-3-PYRIDINECARBOXYLIC ACID;3-Pyridinecarboxylic acid, 2-amino-5-iodo-;2-Amino-5-iodonicotinicacid;SCHEMBL18617035;DTXSID00694766;BCP11517;MFCD10568356;AKOS015854738;AS-5448;AC-25187;3-Pyridinecarboxylic acid,2-amino-5-iodo-;CS-0005555;FT-0698553;I10186

Chemical Property of 2-Amino-5-iodonicotinic acid

Chemical Property:

• PSA: 76.21000
• Density: 2.208
• LogP: 1.54780
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 263.93957
• Heavy Atom Count: 11
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5-iodonicotinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C=NC(=C1C(=O)O)N)I

Technology Process of 2-Amino-5-iodonicotinic acid

There total 1 articles about 2-Amino-5-iodonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-aminopyridin-3-carboxylic acid (5345-47-1) → 2-amino-5-iodo-nicotinic acid (54400-30-5)

Guidance literature:

With N-iodo-succinimide; acetic acid; at 90 ℃; for 4h;

Reference yield: 58.0%

2-amino-5-iodo-nicotinic acid (54400-30-5) + propionic acid anhydride (123-62-6) + 2,6-dimethylaniline (87-62-7) → 3-(2,6-dimethylphenyl)-2-ethyl-6-iodopyrido[2,3-d]pyrimidin-4(3H)-one

Guidance literature:

2-amino-5-iodo-nicotinic acid; propionic acid anhydride; With pyridine; at 0 - 20 ℃; for 0.166667h;

2,6-dimethylaniline; With triphenyl phosphite; for 0.666667h; Microwave irradiation;

Reference yield:

2-amino-5-iodo-nicotinic acid (54400-30-5) → C23H27FN4O2 (1367359-21-4)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide

2: Triethyl orthoacetate / 3 h / Reflux

3: 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride / 1-methyl-pyrrolidin-2-one / 125 - 150 °C

With 2,2,6,6-tetramethylheptane-3,5-dione; benzotriazol-1-ol; caesium carbonate; Triethyl orthoacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; 3: Ullmann coupling;

DOI:10.1016/j.bmcl.2012.01.078

upstream raw materials:

2-aminopyridin-3-carboxylic acid

Downstream raw materials:

C₂₃H₂₇FN₄O₂

C₂₃H₂₆BrFN₄O₂

C₂₉H₃₂N₄O₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 54400-30-5 2-Amino-5-iodo-3-pyridinecarboxylic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send