4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride

Base Information

• Chemical Name: 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride
• CAS No.: 453-67-8
• Molecular Formula: C₃₀H₅₁FN₂O₄*2ClH
• Molecular Weight: 595.666

Synonyms:

Chemical Property of 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride

There total 3 articles about 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-fluorobenzene-1,3-dioic acid (327-95-7) → 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride (453-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: benzene

With thionyl chloride; benzene;

DOI:10.1021/ja01252a016

Reference yield:

2,4-dimethylfluorobenzene (452-65-3) → 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride (453-67-8)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous potassium permanganate

2: thionyl chloride

3: benzene

With potassium permanganate; thionyl chloride; benzene;

DOI:10.1021/ja01252a016

Reference yield:

3-dibutylaminopropanol (2050-51-3) + 4-fluoro-isophthaloyl chloride (327-94-6) → 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride (453-67-8)

Guidance literature:

With benzene;

DOI:10.1021/ja01252a016

upstream raw materials:

3-dibutylaminopropanol

4-fluoro-isophthaloyl chloride

4-fluorobenzene-1,3-dioic acid

2,4-dimethylfluorobenzene

Refernces

New Symmetrical Chiral Dibenzyl- and Diphenyl-Substituted Diamido-, Dithionoamido-, Diaza-, and Azapyridino-18-crown-6 Ligands

10.1021/jo00046a020

The study focuses on the synthesis and characterization of eleven new chiral macrocycles (1-11) of the pyridino-18-crown-6 type. These compounds were prepared using various starting materials such as (S)-(+)-2-phenylglycine, formic acid, acetic anhydride, and diethylene glycol ditosylate, among others. The roles of these chemicals are crucial in the formation of the chiral diamines and glycols, which are then used to create the macrocyclic structures through cyclization reactions with compounds like dimethyl 2,6-pyridinedicarboxylate and O,O'-dimethyl 2,6-pyridinedicarbothioate. The study also investigates the enantiomeric recognition properties of these new chiral ligands with (R)- and (S)-[α-(1-naphthyl)ethyl]ammonium perchlorate using 'H NMR spectral techniques. The interactions and the degree of enantiomeric recognition are analyzed based on the differences in free energy of activation values (ΔG*) and log K values. Additionally, the X-ray analyses of the dithionoamido ligands (2, 6, and 8) reveal significant deviations of the S and N atoms from the plane of the pyridine ring, indicating structural distortions. The study provides insights into the factors influencing enantiomeric recognition and the potential applications of these chiral macrocycles in enantiomeric separations.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 453-67-8 4-fluoro-isophthalic acid bis-(3-dibutylamino-propylester); dihydrochloride

Send

Send

Metric Ton KG G Pound L ML

Send

Send