(2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS No.: 929048-08-8
• Molecular Formula: C18H26N2O4
• Molecular Weight: 334.415
• Hs Code.: 2933990090
• Mol file: 929048-08-8.mol

Synonyms:(S)-2-[[(Benzyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PSA: 67.87000
• Density: 1.137
• LogP: 3.64110

Purity/Quality:

99% ^*data from raw suppliers

(S)-(N-BOC-PYRROLIDIN-2-YL)-N-CBZ-METHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER

There total 1 articles about (2S)-[[[(PHENYLMETHOXY)CARBONYL]AMINO]METHYL]-1-PYRROLIDINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzyl chloroformate (501-53-1,94274-21-2) + (S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (119020-01-8) → 1,1-dimethylethyl (2S)-2-[({[(phenylmethyl)oxy]carbonyl}amino)methyl]-1-pyrrolidinecarboxylate (929048-08-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

1,1-dimethylethyl (2S)-2-[({[(phenylmethyl)oxy]carbonyl}amino)methyl]-1-pyrrolidinecarboxylate (929048-08-8) → phenylmethyl [(2S)-2-pyrrolidinylmethyl]carbamate (913614-65-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 14h;

Reference yield:

1,1-dimethylethyl (2S)-2-[({[(phenylmethyl)oxy]carbonyl}amino)methyl]-1-pyrrolidinecarboxylate (929048-08-8) → (S)-2-(benzyloxycarbonylaminomethyl)pyrrolidine hydrochloride (1217652-74-8,1033245-45-2)

Guidance literature:

With hydrogenchloride; In methanol; water; for 12h;

DOI:10.1021/jm060547+

upstream raw materials:

benzyl chloroformate

(S)-2-(aminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(S)-2-(benzyloxycarbonylaminomethyl)pyrrolidine hydrochloride

2-amino-3,5-dihydro-7-[[(2S)-2-(benzyloxycarbonylaminomethyl)-1-pyrrolidinyl]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one

phenylmethyl [(2S)-2-pyrrolidinylmethyl]carbamate

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