1-CBZ-AMINO-2-BOC-AMINO-ETHANE

Base Information

• Chemical Name: 1-CBZ-AMINO-2-BOC-AMINO-ETHANE
• CAS No.: 77153-05-0
• Molecular Formula: C15H22N2O4
• Molecular Weight: 294.351
• Hs Code.: 2924299090
• Mol file: 77153-05-0.mol

Synonyms:N-(Benzyloxycarbonyl)-N'-(tert-butoxycarbonyl)ethylenediamine

Chemical Property of 1-CBZ-AMINO-2-BOC-AMINO-ETHANE

Chemical Property:

• Melting Point: 123-124oC
• PSA: 76.66000
• Density: 1.121
• LogP: 3.21930

Purity/Quality:

98.5% ^*data from raw suppliers

Benzyltert-butylethane-1,2-diyldicarbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CBZ-AMINO-2-BOC-AMINO-ETHANE

There total 7 articles about 1-CBZ-AMINO-2-BOC-AMINO-ETHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-benzyloxycarbonylaminoethylamine (72080-83-2) → N1-benzyloxycarbonyl-N2-t-butoxycarbonyl-1,2-ethanediamine (77153-05-0)

Guidance literature:

In acetone; 1.) room temp., 24 h, 2.) reflux, 1 h;

DOI:10.1021/jo00325a006

Reference yield: 99.0%

N-tert-butoxycarbonyl-N-tosyl-N'-benzyloxycarbonyl-1,2-ethylenediamine (192320-25-5) → N1-benzyloxycarbonyl-N2-t-butoxycarbonyl-1,2-ethanediamine (77153-05-0)

Guidance literature:

With methanol; magnesium; for 0.333333h; sonication: 35 kHz, 120-240 W;

DOI:10.1039/a701408b

Reference yield: 95.0%

N-BOC-1,2-diaminoethane (57260-73-8) + benzyl chloroformate (501-53-1,94274-21-2) → N1-benzyloxycarbonyl-N2-t-butoxycarbonyl-1,2-ethanediamine (77153-05-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 4.5h;

DOI:10.1021/cc1000105

upstream raw materials:

di-tert-butyl dicarbonate

2-benzyloxycarbonylaminoethylamine

N-tert-butoxycarbonyl-N-tosyl-N'-benzyloxycarbonyl-1,2-ethylenediamine

3-(benzyloxycarbonylamino)propanoic acid

Downstream raw materials:

N-(carbobenzyloxy)ethylenediamine trifluoroacetate

2-benzyloxycarbonylaminoethylamine

Boc-Asp(OBzl)EDA-Z

S-methyl-N-<2-<(tert-butoxycarbonyl)amino>ethyl>-N'-tosylisothiourea