2-(4,ALPHA-DICHLOROBENZYL)PYRIDINE

Base Information

• Chemical Name: 2-(4,ALPHA-DICHLOROBENZYL)PYRIDINE
• CAS No.: 142404-69-1
• Molecular Formula: C12H9 Cl2 N
• Molecular Weight: 238.116
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10931432
• Nikkaji Number: J1.640.292C
• Mol file: 142404-69-1.mol

Synonyms:2-(4,ALPHA-DICHLOROBENZYL)PYRIDINE;2-[Chloro(4-chlorophenyl)methyl]pyridine;Ccris 5988;Pyridine, 2-[chloro(4-chlorophenyl)Methyl]-

Chemical Property of 2-(4,ALPHA-DICHLOROBENZYL)PYRIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 338.733oC at 760 mmHg
• PKA: 4.22±0.10(Predicted)
• Flash Point: 189.141°C
• PSA: 12.89000
• Density: 1.279
• LogP: 4.06320
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 237.0112047
• Heavy Atom Count: 15
• Complexity: 190

Purity/Quality:

99%, ^*data from raw suppliers

2-(Chloro(4-chlorophenyl)methyl)pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C(C2=CC=C(C=C2)Cl)Cl

Technology Process of 2-(4,ALPHA-DICHLOROBENZYL)PYRIDINE

There total 1 articles about 2-(4,ALPHA-DICHLOROBENZYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-chlorophenyl)-2-pyridylmethanol (27652-89-7) → 2-[chloro(4-chlorophenyl)methyl]pyridine (142404-69-1)

Guidance literature:

With thionyl chloride; In toluene; at 0 - 25 ℃; for 3h;

DOI:10.1021/jm970462w

Reference yield: 87.0%

4-(4-hydroxypiperidin-1-yl)butanoic acid ethyl ester + 2-[chloro(4-chlorophenyl)methyl]pyridine (142404-69-1) → 4-(4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl)butanoic acid (190786-43-7,190730-41-7)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 60 ℃; for 5h; Inert atmosphere;

Reference yield: 83.0%

4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester (138022-02-3) + 2-[chloro(4-chlorophenyl)methyl]pyridine (142404-69-1) → tert-butyl 4-((((4-chlorophenyl)(pyridin-2-yl)methyl)(methyl)amino)methyl)piperidine-1-carboxylate

Guidance literature:

With potassium carbonate; In acetonitrile; at 80 ℃; for 6h;

upstream raw materials:

(4-chlorophenyl)-2-pyridylmethanol

Downstream raw materials:

1-[4-chlorophenyl-(pyridin-2-yl)methyl]piperazine

4-[(4-chlorophenyl)(pyridin-2-yl)methoxy]piperidine

4-(4-[(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl)butanoic acid

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