(R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one

Base Information

Chemical Name:(R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one
CAS No.:109355-84-2
Molecular Formula:C₄₅H₄₈N₂O₆
Molecular Weight:712.886
Hs Code.:

(R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one

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Chemical Property of (R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one

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Technology Process of (R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one

There total 17 articles about (R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 109355-83-1
(6S,8E,10E,12E)-4,4-ethylenedioxy-1-(imidazol-1-yl)-6,12-dimethyltetradeca-8,10,12-trien-1-one

: 109355-78-4
(5R)-1-benzoyl-5-(1-benzoylindol-3-ylmethyl)pyrrolidin-2-one

: 109355-84-2,109430-49-1
(R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one

Guidance literature:: With lithium hexamethyldisilazane;
DOI:10.1039/c39860001447

Reference yield:

: 139091-30-8,109364-32-1
(S)-benzyl (1-(indol-3-yl)-3-oxopropan-2-yl)carbamate

: 109355-84-2,109430-49-1
(R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / LDA

2: 81 percent / H₂, AcOH / Pd/C / ethanol

3: 95 percent / NaOEt / ethanol

4: 77 percent / Et₃N, DMAP

5: 68 percent / LiN(SiMe₃)2

With dmap; hydrogen; sodium ethanolate; acetic acid; triethylamine; lithium hexamethyldisilazane; lithium diisopropyl amide; palladium on activated charcoal; In ethanol;
DOI:10.1039/c39860001447

Reference yield:

: 2717-76-2,130812-44-1,130812-46-3
(S)-N-benzyloxycarbonyl-L-tryptophan methyl ester

: 109355-84-2,109430-49-1
(R)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 73 percent / i-Bu₂AlH

2: 70 percent / LDA

3: 81 percent / H₂, AcOH / Pd/C / ethanol

4: 95 percent / NaOEt / ethanol

5: 77 percent / Et₃N, DMAP

6: 68 percent / LiN(SiMe₃)2

With dmap; hydrogen; sodium ethanolate; diisobutylaluminium hydride; acetic acid; triethylamine; lithium hexamethyldisilazane; lithium diisopropyl amide; palladium on activated charcoal; In ethanol;
DOI:10.1039/c39860001447