Technology Process of Methionyl-tyrosyl-glycyl-glycyl-phenylalanyl-leucine
There total 7 articles about Methionyl-tyrosyl-glycyl-glycyl-phenylalanyl-leucine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 72 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C
2: hydrogen / palladium black / 2-methyl-propan-2-ol / 8 h
3: dicyclohexylcarbodiimide / CHCl3 / 3 h / -20 - 0 °C / r.t., overnight
4: 86 percent / hydrogen / palladium black / 2-methyl-propan-2-ol / 16 h
5: trifluoroacetic acid
6: 73 percent / N-methylmorpholine / dimethylformamide / 120 h / Ambient temperature
7: trifluoroacetic acid / 0.42 h / Ambient temperature
With
4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium;
In
chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1135/cccc19851329
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dicyclohexylcarbodiimide / CHCl3 / 3 h / -20 - 0 °C / r.t., overnight
2: 86 percent / hydrogen / palladium black / 2-methyl-propan-2-ol / 16 h
3: trifluoroacetic acid
4: 73 percent / N-methylmorpholine / dimethylformamide / 120 h / Ambient temperature
5: trifluoroacetic acid / 0.42 h / Ambient temperature
With
4-methyl-morpholine; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium;
In
chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1135/cccc19851329
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogen / palladium black / 2-methyl-propan-2-ol / 8 h
2: dicyclohexylcarbodiimide / CHCl3 / 3 h / -20 - 0 °C / r.t., overnight
3: 86 percent / hydrogen / palladium black / 2-methyl-propan-2-ol / 16 h
4: trifluoroacetic acid
5: 73 percent / N-methylmorpholine / dimethylformamide / 120 h / Ambient temperature
6: trifluoroacetic acid / 0.42 h / Ambient temperature
With
4-methyl-morpholine; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium;
In
chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1135/cccc19851329
