Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester

Base Information

• Chemical Name: Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester
• CAS No.: 75412-29-2
• Molecular Formula: C₂₅H₃₅NO₉
• Molecular Weight: 493.554

Synonyms:

Chemical Property of Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester

There total 19 articles about Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

benzyl 4-O-(3,4-di-O-acetyl-2,6-didesoxy-α-L-lyxo-hexopyranosyl)-3-azido-2,3,6-tridesoxy-α-D-erythro-hex-5-enopyranoside (75412-38-3) → Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester (75412-29-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; 1.) AcOEt; Ac₂O; NEt₃;

DOI:10.1016/S0040-4039(00)93163-0

Reference yield:

(4aR,6S,8R,8aS)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-ol (6752-48-3) → Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester (75412-29-2)

Guidance literature:

Multi-step reaction with 13 steps

1: pyridine

2: 79 percent / NaN₃ / hexamethylphosphoric acid triamide / 4 h / 150 °C

3: NBS / CCl₄ / Heating

4: CH₃ONa

5: 60 percent / TSOH / benzene / 2 h / Ambient temperature

6: 60 percent / AgF / pyridine

7: 68 percent / H₂ / 10percent Pd/C / ethanol

8: Ba(OH)2

10: 1.) aq. CH₃COOH; 2.) pyridine

11: 50 percent

12: 30 percent / AgF

13: 50 percent / 1.) H₂; / 10percent Pd/C / 1.) AcOEt; Ac₂O; NEt₃

With pyridine; barium dihydroxide; N-Bromosuccinimide; sodium azide; hydrogen; sodium methylate; silver fluoride; toluene-4-sulfonic acid; acetic acid; palladium on activated charcoal; In pyridine; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; benzene;

DOI:10.1016/S0040-4039(00)93163-0

Reference yield:

Methanesulfonic acid (4aR,6R,8R,8aR)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester (62774-38-3) → Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester (75412-29-2)

Guidance literature:

Multi-step reaction with 12 steps

1: 79 percent / NaN₃ / hexamethylphosphoric acid triamide / 4 h / 150 °C

2: NBS / CCl₄ / Heating

3: CH₃ONa

4: 60 percent / TSOH / benzene / 2 h / Ambient temperature

5: 60 percent / AgF / pyridine

6: 68 percent / H₂ / 10percent Pd/C / ethanol

7: Ba(OH)2

9: 1.) aq. CH₃COOH; 2.) pyridine

10: 50 percent

11: 30 percent / AgF

12: 50 percent / 1.) H₂; / 10percent Pd/C / 1.) AcOEt; Ac₂O; NEt₃

With pyridine; barium dihydroxide; N-Bromosuccinimide; sodium azide; hydrogen; sodium methylate; silver fluoride; toluene-4-sulfonic acid; acetic acid; palladium on activated charcoal; In pyridine; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; benzene;

DOI:10.1016/S0040-4039(00)93163-0

upstream raw materials:

benzyl 4-O-(3,4-di-O-acetyl-2,6-didesoxy-α-L-lyxo-hexopyranosyl)-3-azido-2,3,6-tridesoxy-α-D-erythro-hex-5-enopyranoside

(4aR,6S,8R,8aS)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-ol

Methanesulfonic acid (4aR,6R,8R,8aR)-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester

acetyl-di-O-acetyl-3,4 didesoxy-2,6 L-lyxo-hexopyrannose

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 75412-29-2 Acetic acid (2S,3R,4S,6S)-3-acetoxy-6-((2S,3S,4S,6S)-4-acetylamino-6-benzyloxy-2-methyl-tetrahydro-pyran-3-yloxy)-2-methyl-tetrahydro-pyran-4-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send