3-Ethoxy-2-propenoyl isocyanate

Base Information

• Chemical Name: 3-Ethoxy-2-propenoyl isocyanate
• CAS No.: 928778-13-6
• Molecular Formula: C₆H₇NO₃
• Molecular Weight: 141.126
• Mol file: 928778-13-6.mol

Synonyms:LogP

Chemical Property of 3-Ethoxy-2-propenoyl isocyanate

Chemical Property:

• Vapor Pressure: 0.364mmHg at 25°C
• Boiling Point: 130.7±32.0 °C (760 mmHg)
• Flash Point: 84.5°C
• PSA: 38.66000
• Density: 1.05g/cm³
• LogP: 0.82990

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Ethoxy-2-propenoyl isocyanate

There total 10 articles about 3-Ethoxy-2-propenoyl isocyanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitrophenyl 3-ethoxyacryloylcarbamate (1271239-29-2) → (3-ethoxy-acryloyl)isocyanate (57796-78-8,928778-13-6) + 2-hydroxynitrobenzene (88-75-5,78813-12-4)

Guidance literature:

In chloroform-d1; at 25 ℃; Kinetics;

DOI:10.1002/poc.1775

Reference yield:

(2E)-3-ethoxyprop-2-enoyl chloride (6191-99-7,99471-66-6) + silver cyanate (3315-16-0) → (E)-3-ethoxypropenoyl isocyanate (115983-78-3,928778-13-6)

Guidance literature:

In benzene; for 3h; Ambient temperature;

DOI:10.1248/cpb.39.1682

Reference yield:

3-ethoxyacryloyl chloride (6191-99-7) + silver cyanate (3315-16-0) → (3-ethoxy-acryloyl)isocyanate (57796-78-8,928778-13-6)

Guidance literature:

In benzene; reflux, 0.5 h, RT, 2.5 h;

DOI:10.1139/v85-464

upstream raw materials:

chlorocarbonyl isocyanate

ethyl vinyl ether

3-ethoxyacryloyl chloride

silver cyanate

Downstream raw materials:

2-nitrophenyl 3-ethoxyacryloylcarbamate

1-((1S,3S,4R,5S)-3-Benzyloxy-4-benzyloxymethyl-bicyclo[3.1.0]hex-1-yl)-3-((E)-3-ethoxy-acryloyl)-urea

N-<<<(2S,4S)-2-(O-benzoylmethyl)tetrahydrofuranyl>amino>carbonyl>-3-ethoxy-2-propenamide

Benzoic acid (1R,2R,4R)-2-benzyloxymethyl-4-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentylmethyl ester

Refernces

• 1、 Wang, Mengmeng,Srivastava, Puneet,Liu, Chao,Snoeck, Robert,Andrei, Graciela,De Jonghe, Steven,Herdewijn, Piet. "Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates". . p. 616 - 625. Retrieved 2018/03/21.
• 2、 Rygielska-Tokarska, Dorota,Andrei, Graciela,Schols, Dominique,Snoeck, Robert,G?owacka, Iwona E.. "Synthesis, antiviral, cytotoxic and cytostatic evaluation of N1-(Phosphonoalkyl)uracil derivatives". . p. 1081 - 1090. Retrieved 2017/01/11.