CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester

Base Information

• Chemical Name: CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester
• CAS No.: 1220910-89-3
• Molecular Formula: C21H17FN6O2
• Molecular Weight: 404.403
• Mol file: 1220910-89-3.mol

Synonyms:CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester;N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester;N-[3-Fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]carbaMic acid phenylMethyl ester;benzyl (3-fluoro-4-(6-(2-Methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)carbaMate;Torezolid Intermediate1;N- [3- fluoro-4- [6- (2-methyl--2H- tetrazol-5-yl) -3-pyridinyl] phenyl] carbamate

Chemical Property of CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester

Chemical Property:

• PKA: 12.52±0.70(Predicted)
• PSA: 98.31000
• Density: 1.36±0.1 g/cm3(Predicted)
• LogP: 3.84050
• Storage Temp.: 2-8°C
• Solubility.: Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.5%+ ^*data from raw suppliers

N-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]carbamicAcidPhenylmethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]carbamic Acid Phenylmethyl Ester is an intermediate in the synthesis of Tedizolid (T013750), an known oral and intravenous antibiotic.

Technology Process of CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester

There total 20 articles about CarbaMic acid, N-[3-fluoro-4-[6-(2-Methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-, phenylMethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)aniline + benzyl chloroformate (501-53-1,94274-21-2) → 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester (1220910-89-3)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 88.0%

2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1056039-83-8) + (4-bromo-3-fluorophenyl)carbamic acid benzyl ester (510729-01-8) → 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester (1220910-89-3)

Guidance literature:

With potassium carbonate; In water; at 80 ℃; for 12h; Inert atmosphere;

Reference yield: 87.0%

2-fluoro-4-(benzyloxycarbonyl)aminophenylboronic acid (874290-59-2) + 5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine (380380-64-3) → 3-fluoro-4-(6-(2-methyl-2H-tetrazole-5-yl)pyridin-3-yl)phenyl-carbamic acid benzylester (1220910-89-3)

Guidance literature:

With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; at 70 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-fluoro-4-(benzyloxycarbonyl)aminophenylboronic acid

5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine

2-(2-methyl-2H-tetrazol-5-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

(4-bromo-3-fluorophenyl)carbamic acid benzyl ester

Downstream raw materials:

(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridra-3-yl]phenyl}-5-(hydroxymethyl)-1,3-oxazoiidin-2-one

(R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate