Methyl (2E)-3-cyclohexylprop-2-enoate

Base Information

• Chemical Name: Methyl (2E)-3-cyclohexylprop-2-enoate
• CAS No.: 26429-99-2
• Molecular Formula: C10H16O2
• Molecular Weight: 168.236
• Hs Code.: 2916209090
• Mol file: 26429-99-2.mol

Synonyms:2-Propenoic acid,3-cyclohexyl-, methyl ester, (E)-;Cyclohexaneacrylic acid, methyl ester, (E)-(8CI);Methyl (2E)-3-cyclohexylpropenoate;trans-b-Cyclohexylacrylic acid, methyl ester;

Chemical Property of Methyl (2E)-3-cyclohexylprop-2-enoate

Chemical Property:

• Boiling Point: 227.1 °C at 760 mmHg
• Flash Point: 103.2 °C
• PSA: 26.30000
• Density: 1.036 g/cm³
• LogP: 2.29590

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl (2E)-3-cyclohexylprop-2-enoate

There total 27 articles about Methyl (2E)-3-cyclohexylprop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) + cyclohexanecarbaldehyde (2043-61-0) → methyl (2E)-3-cyclohexylprop-2-enoate (26429-99-2)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja105161f

Reference yield: 87.0%

dichloroacetic acid methyl ester (116-54-1) + cyclohexanecarbaldehyde (2043-61-0) → methyl (2E)-3-cyclohexylprop-2-enoate (26429-99-2)

Guidance literature:

With manganese; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/jo070209w

Reference yield: 84.0%

methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) + cyclohexylmethyl alcohol (100-49-2) → (Z)-methyl 3-cyclohexyl-2-propenoate (26429-98-1) + methyl (2E)-3-cyclohexylprop-2-enoate (26429-99-2)

Guidance literature:

cyclohexylmethyl alcohol; With Celite; pyridinium chlorochromate; In dichloromethane; at 20 ℃;

methyl (triphenylphosphoranylidene)acetate; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-2004-817762

upstream raw materials:

methanol

carbon monoxide

C₈H₁₃ClHg

methyl diazoacetate

Downstream raw materials:

2-((E)-2-cyclohexyl-vinyl)-4,5-dihydro-1H-imidazole

3-cyclohexyl-2-hydroxy-3-oxo-propionic acid methyl ester

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6". Paragraph 00393; 00417. . Retrieved 2021/09/04.
• 2、 -. "1-PHENYLPYRROLIDIN-2-ONE DERIVATIVES AS PERK INHIBITORS". Page/Page column 103. . Retrieved 2017/04/11.