N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide)

Base Information

• Chemical Name: N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide)
• CAS No.: 104295-15-0
• Molecular Formula: C₂₅H₂₈N₂O₄
• Molecular Weight: 420.508
• Mol file: 104295-15-0.mol

Synonyms:

Chemical Property of N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide)

There total 5 articles about N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dinitronaphthalene (606-37-1) → N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide) (104295-15-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Na₂S; NaHCO₃; aqueous methanol / bei der Reduktion

2: aqueous HCl

3: dimethyl sulfate; K₂CO₃; acetone

4: palladium/charcoal; methanol / Hydrogenation

5: dicyclohexylcarbodiimide; CH₂Cl₂

With hydrogenchloride; methanol; sodium sulfide; palladium on activated charcoal; dichloromethane; sodium hydrogencarbonate; potassium carbonate; dicyclohexyl-carbodiimide; acetone; dimethyl sulfate;

DOI:10.1021/ja01543a029

Reference yield:

3-Nitro-1-naphthol (19256-80-5) → N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide) (104295-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfate; K₂CO₃; acetone

2: palladium/charcoal; methanol / Hydrogenation

3: dicyclohexylcarbodiimide; CH₂Cl₂

With methanol; palladium on activated charcoal; dichloromethane; potassium carbonate; dicyclohexyl-carbodiimide; acetone; dimethyl sulfate;

DOI:10.1021/ja01543a029

Reference yield:

1-Methoxy-3-nitronaphthalene (13802-40-9) → N-benzyloxycarbonyl-L-leucine-(4-methoxy-[2]naphthylamide) (104295-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium/charcoal; methanol / Hydrogenation

2: dicyclohexylcarbodiimide; CH₂Cl₂

With methanol; palladium on activated charcoal; dichloromethane; dicyclohexyl-carbodiimide;

DOI:10.1021/ja01543a029

upstream raw materials:

Z-Leu-OH

4-methoxy-2-naphthylamine

2,4-dinitronaphthalene

3-Nitro-1-naphthol

Downstream raw materials:

L-leucine-4-methoxy-2-naphthylamide