Naluzotan

Base Information

Chemical Name:Naluzotan
CAS No.:740873-06-7
Molecular Formula:C23H38N4O3S
Molecular Weight:450.646
Hs Code.:
UNII:LQ54E5B4EW
ChEMBL ID:CHEMBL209821
DSSTox Substance ID:DTXSID40995527
Metabolomics Workbench ID:149517
NCI Thesaurus Code:C80775
Pharos Ligand ID:YW7G6F7964PQ
Wikidata:Q6961039
Wikipedia:Naluzotan
Mol file:740873-06-7.mol

Synonyms:N-(3-(4-(4-cyclohexylmethanesulfonylaminobutyl)piperazin-1-yl)phenyl)acetamide;naluzotan;PRX 00023;PRX-00023;PRX00023

Suppliers and Price of Naluzotan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
PRX-00023 95.00%
5MG
$ 502.46

Total 13 raw suppliers

Chemical Property of Naluzotan

Chemical Property:

PKA:11.49±0.40(Predicted)
PSA：93.62000
Density:1.169
LogP:5.17100
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:450.26646226
Heavy Atom Count:31
Complexity:638

Purity/Quality:

97% ^*data from raw suppliers

PRX-00023 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)NC1=CC(=CC=C1)N2CCN(CC2)CCCCNS(=O)(=O)CC3CCCCC3
Recent ClinicalTrials:PRX-00023 Therapy in Localization-Related Epilepsy

Technology Process of Naluzotan

There total 6 articles about Naluzotan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 740873-05-6
N-{4-[4-(3-aminophenyl)piperazin-1-yl]butyl}-C-cyclohexylmethanesulfonamide

: 75-36-5
acetyl chloride

: 740873-06-7
Naluzotan

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm0508641

Reference yield:

: 54054-85-2
1-(3-nitrophenyl)piperazine

: 740873-06-7
Naluzotan

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / Et₃N / tetrahydrofuran / 48 h / 20 °C

2: CH₂Cl₂ / 2 h / 0 °C

3: 88 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

4: 76 percent / SnCl₂; aq. HCl / methanol / -10 - 20 °C

5: 89 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0508641

Reference yield:

: 740873-01-2
{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}carbamic acid tert-butyl ester

: 740873-06-7
Naluzotan

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 2 h / 0 °C

2: 88 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

3: 76 percent / SnCl₂; aq. HCl / methanol / -10 - 20 °C

4: 89 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With hydrogenchloride; triethylamine; tin(ll) chloride; In methanol; dichloromethane;
DOI:10.1021/jm0508641