semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile

Base Information

• Chemical Name: semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile
• CAS No.: 77742-49-5
• Molecular Formula: C₃₁H₃₂N₄O₅
• Molecular Weight: 540.619

Synonyms:

Chemical Property of semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile

Chemical Property:

Purity/Quality:

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Technology Process of semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile

There total 2 articles about semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile (77668-04-3) → semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile (77742-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 34 g / 50percent sodium hydride in mineral oil / diethyl ether; ethanol / 15 h

2: CH₂Cl₂; H₂O / 20 h

With sodium hydride; In diethyl ether; ethanol; dichloromethane; water;

Reference yield:

semicarbazide hydrochloride (563-41-7) + 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile (77715-28-7) → semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile (77742-49-5)

Guidance literature:

In dichloromethane; water; for 20h;

Reference yield:

semicarbazone of 2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile (77742-49-5) → 4-(β-2,3-O-isopropylidene-5-O-tritylribofuranosyl)-3-aminopyrazole (59220-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.5 g / sodium ethoxide / ethanol / 0.17 h / Ambient temperature

2: methanol / 0.08 h / 50 - 60 °C

With sodium ethanolate; In methanol; ethanol;

upstream raw materials:

semicarbazide hydrochloride

2-formyl-2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile

2-(2,3-O-isopropylidene-5-O-trityl-D-ribofuranosyl)acetonitrile

Downstream raw materials:

3-amino-2N-carbamoyl-4-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)pyrazole

3-amino-2N-carbamoyl-4-(2,3-O-isopropylidene-5-O-trityl-β-D-ribofuranosyl)pyrazole

(1R)-D-1-(3-amino-1⁽²⁾H-pyrazol-4-yl)-O²,O³-isopropylidene-O⁵-trityl-1,4-anhydro-ribitol

4-(β-2,3-O-isopropylidene-5-O-tritylribofuranosyl)-3-aminopyrazole

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