(2-Fluoro-3-nitrophenyl)methanol

Base Information

• Chemical Name: (2-Fluoro-3-nitrophenyl)methanol
• CAS No.: 946126-95-0
• Molecular Formula: C7H6 F N O3
• Molecular Weight: 171.128
• Hs Code.: 2906299090
• Mol file: 946126-95-0.mol

Synonyms:(2-Fluoro-3-nitrophenyl)methanol

Chemical Property of (2-Fluoro-3-nitrophenyl)methanol

Chemical Property:

• Vapor Pressure: 7.52E-05mmHg at 25°C
• Boiling Point: 328.7oC at 760 mmHg
• PKA: 13.34±0.10(Predicted)
• Flash Point: 152.6oC
• PSA: 66.05000
• Density: 1.434g/cm3
• LogP: 1.74940
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Fluoro-3-nitrobenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-3-nitrobenzyl Alcohol is used to prepare 2-oxo-2H-benzopyran derivatives as P27 protein inducers to treat diseases accompanying cell proliferation such as cancer, rheumatism and inflammations.

Technology Process of (2-Fluoro-3-nitrophenyl)methanol

There total 5 articles about (2-Fluoro-3-nitrophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

2-fluoro-3-nitro-benzoic acid (317-46-4) → (2-fluoro-3-nitrophenyl)methanol (946126-95-0)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 19h; Inert atmosphere;

DOI:10.1039/d0md00034e

Reference yield: 95.0%

2-fluoro-3-nitrobenzoic acid methyl ester (946126-94-9) → (2-fluoro-3-nitrophenyl)methanol (946126-95-0)

Guidance literature:

2-fluoro-3-nitrobenzoic acid methyl ester; With diisobutylaluminium hydride; In toluene; at -78 - 0 ℃; for 1h;

With water; rochelle salt; In methanol; toluene; at -78 - 20 ℃; for 1h;

Reference yield: 90.0%

→ (2-fluoro-3-nitrophenyl)methanol (946126-95-0)

Guidance literature:

With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.5h;

With sodium tetrahydroborate; at 20 ℃; for 2h;

upstream raw materials:

2-fluoro-3-nitrobenzoic acid methyl ester

2-fluoro-3-nitro-benzoic acid

2-chloro-3-nitrobenzoic acid methyl ester

2-chloro-3-nitrobezoic acid

Downstream raw materials:

1-(bromomethyl)-2-fluoro-3- nitrobenzene

(3-amino-2-fluorophenyl)methanol

4-methyl-3-(2-fluoro-3-aminobenzyl)-7-(thiazol-2-yloxy)-2-oxo-2H-1-benzopyran

3-{2-fluoro-3-aminobenzyl}-4-methyl-7-(5-fluoropyrimidin-2-yloxy)-2-oxo-2H-1-benzopyran

Refernces

• 1、 -. "THERAPEUTIC COMPOUNDS". Paragraph 0395; 0396; 0399. . Retrieved 2017/01/23.
• 2、 -. "p27 PROTEIN INDUCER". . . Retrieved 2010/04/25.