317-46-4

Basic information

• Product Name: 2-FLUORO-3-NITROBENZOIC ACID
• Synonyms: Benzoic acid,2-fluoro-3-nitro-;2-FLUORO-3-NITROBENZOIC ACID;2-Fluoro-3-nitrobenzoic acid+B244;2-Fluoro-3-nitrobenzoic acid 99%;3-Carboxy-2-fluoronitrobenzene;3-Pyridinecarboxylic acid, 4-aMino-
• CAS NO: 317-46-4
• Molecular Formula: C₇H₄FNO₄
• Molecular Weight: 185.11
• EINECS: 1312995-182-4
• Product Categories: Fluorine series;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 317-46-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 347.6 °C at 760 mmHg
• Flash Point: 164 °C
• Appearance: /Solid
• Density: 1.568 g/cm³
• Vapor Pressure: 2.01E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: 2-8°C
• Solubility: DMSO (Sparingly), Methanol (Slightly)
• PKA: 2.32±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Air Sensitive
• Stability: Hygroscopic
• CAS DataBase Reference: 2-FLUORO-3-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-NITROBENZOIC ACID(317-46-4)
• EPA Substance Registry System: 2-FLUORO-3-NITROBENZOIC ACID(317-46-4)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• Hazardous Substances Data: 317-46-4(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow crystalline powder

Uses

2-Fluoro-3-nitrobenzoic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C7H4FNO4/c8-6-4(7(10)11)2-1-3-5(6)9(12)13/h1-3H,(H,10,11)

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 96516-29-9 2-fluoro-3-nitrobenzaldehyde 
• 95-48-7 ortho-cresol 
• 13073-29-5 2-methyl-6-nitrophenol 
• 124-38-9 carbon dioxide 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1214328-20-7 2-fluoro-3-nitrobenzonitrile 
• 95-52-3 2-Fluorotoluene 

Downstream Products

• 1254567-33-3 (3-amino-2-fluorophenyl)(5-bromo-1H-pyrrolo[2,3-b]pyridin- 3-yl)methanone 
• 1312942-00-9 (5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(2-fluoro-3-nitrophenyl)methanone 
• 1312942-01-0 N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-2-fluoro-benzenesulfonamide 
• 1312940-70-7 2-fluoro-N-{2-fluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-benzenesulfonamide 
• 1378870-43-9 2-fluoro-N-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-3-nitro-benzamide 
• 1378870-46-2 2-methoxy-N-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-3-nitro-benzamide 
• 1378870-48-4 3-amino-2-methoxy-N-(2-methyl-5-pentafluoroethyl-4-trifluoromethyl-2H-pyrazol-3-yl)-benzamide 
• 1446148-22-6 tert-butyl-((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(2-fluoro-N-isopropyl-3-nitrobenzamido)-3-methylbutyl)(methyl)carbamate 
• 1446148-10-2 C₂₆H₃₂ClN₃O₅S 
• 1254318-25-6 3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide 
• 1254318-22-3 N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy-3-nitrobenzamide 
• 1254318-20-1 N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-fluoro-3-nitrobenzamide 
• 1309431-17-1 2,5-difluoro-N-(2-fluoro-3-formyl-phenyl)-benzenesulfonamide 
• 1309431-16-0 2,5-difluoro-N-(2-fluoro-3-hydroxymethyl-phenyl)-benzenesulfonamide 

Relevant articles and documents

Synthesis method of 2-fluoro-3-nitrobenzoic acid intermediate raw material

The invention discloses a synthesis method of a 2-fluoro-3-nitrobenzoic acid intermediate raw material. The invention provides a novel synthesis route, and an important medical intermediate can be rapidly and conveniently prepared from cheap and easily available raw materials. The process method comprises the following steps: starting from o-methylphenol, carrying out nitration reaction to selectively generate a key intermediate 2-methyl-6-nitrophenol, carrying out hydroxyl chlorination to generate 2-chloro-3-nitrotoluene, then carrying out fluorination reaction to generate 2-fluoro-3-nitrotoluene, and finally oxidizing methyl under the action of an oxidant to generate 2-fluoro-3-nitrobenzoic acid. The method is not only high in yield, but also suitable for large-scale production.

IMINOTETRAHYDROPYRIMIDINONE DERIVATIVES AS PLASMEPSIN V INHIBITORS

A series of 2-imino-6-methyltetrahydropyrimidin-4(lH)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.