4-[4-(TRIFLUOROMETHYL)PHENOXY]PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-[4-(TRIFLUOROMETHYL)PHENOXY]PIPERIDINE HYDROCHLORIDE
• CAS No.: 287952-09-4
• Molecular Formula: C₁₂H₁₄F₃NO*ClH
• Molecular Weight: 281.705
• Hs Code.: 2933399090
• Mol file: 287952-09-4.mol

Synonyms:Piperidine,4-[4-(trifluoromethyl)phenoxy]-, hydrochloride (9CI); 4-[4-(Trifluoromethyl)phenoxy]piperidiniumchloride; [4-(4-Trifluoromethyl)phenoxy]piperidine hydrochloride

Chemical Property of 4-[4-(TRIFLUOROMETHYL)PHENOXY]PIPERIDINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000127mmHg at 25°C
• Boiling Point: 329.6oC at 760 mmHg
• Flash Point: 153.1oC
• PSA: 38.91000
• LogP: 4.06520
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-(4-(Trifluoromethyl)phenoxy)piperidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[4-(TRIFLUOROMETHYL)PHENOXY]PIPERIDINE HYDROCHLORIDE

There total 5 articles about 4-[4-(TRIFLUOROMETHYL)PHENOXY]PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

tert-butyl 4-(4-(trifluoromethyl)phenoxy)piperidine-1-carboxylate (287952-08-3) → 4-[4-(trifluoromethyl)phenoxy]piperidine hydrogen chloride salt (287952-09-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/S0960-894X(00)00584-9

Reference yield:

4-hydroxybenzotrifluoride (402-45-9) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 3,5-Dichloro-2-(4-piperidinyloxy)pyridine dihydrochloride + 4-[4-(trifluoromethyl)phenoxy]piperidine hydrogen chloride salt (287952-09-4)

Guidance literature:

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → 4-[4-(trifluoromethyl)phenoxy]piperidine hydrogen chloride salt (287952-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / tetrahydrofuran / 0 °C

2: 81 percent / Cs₂CO₃ / dimethylformamide / 48 h / 120 °C

3: 88 percent / 4N HCl / dioxane

With hydrogenchloride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(00)00584-9

upstream raw materials:

tert-butyl 4-(4-(trifluoromethyl)phenoxy)piperidine-1-carboxylate

4-HYDROXYPIPERIDINE

t-butyl 4-hydroxy piperidine-1-carboxylate

4-hydroxybenzotrifluoride

Downstream raw materials:

N-(2-(1H-1,2,3-triazol-4-yl)propan-2-yl)-4-(4-(trifluoromethyl)phenoxy)piperidine-1-sulfonamide

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