1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one

Base Information

Chemical Name:1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one
CAS No.:1014700-68-5
Molecular Formula:C₃₁H₄₂FN₅O₂
Molecular Weight:535.705
Hs Code.:

1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one

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Chemical Property of 1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one

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Technology Process of 1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one

There total 8 articles about 1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 878130-37-1
4-cyanomethyl-4-(3-fluoro-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1014700-68-5
1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: diisobutylaluminium hydride / dichloromethane / 4 h / -78 - -60 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

3: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / ethanol / 21 h / 20 °C / 760.05 Torr

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5: hydrogenchloride / 1,4-dioxane; methanol; diethyl ether / 5 h / 20 - 40 °C

6: pyridine / dichloromethane / 24 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 1014700-68-5
1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: copper(l) iodide / tetrahydrofuran / 3 h / 0 °C

2.1: sodium hydroxide / ethanol; water / 15 h / 20 °C

2.2: 0 °C / pH 3

3.1: copper(I) oxide / acetonitrile / 1 - 1.25 h / Heating / reflux

4.1: diisobutylaluminium hydride / dichloromethane / 4 h / -78 - -60 °C

5.1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / ethanol / 21 h / 20 °C / 760.05 Torr

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

8.1: hydrogenchloride / 1,4-dioxane; methanol; diethyl ether / 5 h / 20 - 40 °C

9.1: pyridine / dichloromethane / 24 h / 20 °C

With pyridine; copper(I) oxide; hydrogenchloride; sodium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; copper(l) iodide; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 878130-44-0
4-(3-fluoro-phenyl)-4-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1014700-68-5
1-[4-{2-[5-(4,6-dimethyl-pyrimidine-5-carbonyl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-ethyl}-4-(3-fluoro-phenyl)-piperidin-1-yl]-2,2-dimethyl-propan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 2 h / 20 °C

2: hydrogen / palladium 10% on activated carbon; palladium(II) hydroxide/carbon / ethanol / 21 h / 20 °C / 760.05 Torr

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

4: hydrogenchloride / 1,4-dioxane; methanol; diethyl ether / 5 h / 20 - 40 °C

5: pyridine / dichloromethane / 24 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium(II) hydroxide/carbon; palladium 10% on activated carbon; In 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane;