5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE

Base Information

• Chemical Name: 5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE
• CAS No.: 148214-56-6
• Molecular Formula: C5H6 Br N3 O
• Molecular Weight: 204.026
• Hs Code.: 2933599090
• Mol file: 148214-56-6.mol

Synonyms:5-Brom-2-methoxy-pyrimidin-4-ylamin;4-Pyrimidinamine,5-bromo-2-methoxy;5-Bromo-2-methoxypyrimidin-4-ylamine;5-bromo-2-methoxy-pyrimidin-4-ylamine;

Chemical Property of 5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE

Chemical Property:

• Vapor Pressure: 0.000148mmHg at 25°C
• Melting Point: 134-136 °C
• Boiling Point: 332.3oC at 760 mmHg
• PKA: 3.35±0.10(Predicted)
• Flash Point: 154.7oC
• PSA: 61.03000
• Density: 1.723g/cm3
• LogP: 1.41110
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromo-2-methoxypyrimidin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE

There total 2 articles about 5-BROMO-2-METHOXYPYRIMIDIN-4-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

sodium methylate (124-41-4) + 4-amino-5-bromo-2-chloropyrimidine (205672-25-9) → 5-bromo-2-methoxypyrimidin-4-amine (148214-56-6)

Guidance literature:

In methanol; for 2h; Reflux;

Reference yield:

5-bromo-2,4-dimethoxypyrimidine (56686-16-9) → 5-bromo-2-methoxypyrimidin-4-amine (148214-56-6)

Guidance literature:

With methanol; ammonia;

DOI:10.1021/ja01316a041

Reference yield:

5-bromo-2-methoxypyrimidin-4-amine (148214-56-6) → 5-bromocytosine (2240-25-7)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01316a041

upstream raw materials:

5-bromo-2,4-dimethoxypyrimidine

sodium methylate

4-amino-5-bromo-2-chloropyrimidine

Downstream raw materials:

5-bromocytosine

Refernces

• 1、 -. "PROGNOSTIC BIOMARKERS FOR TTK INHIBITOR CHEMOTHERAPY". Page/Page column 29. . Retrieved 2016/10/31.