4-(6-Chloropyridazin-3-yl)benzaldehyde

Base Information

• Chemical Name: 4-(6-Chloropyridazin-3-yl)benzaldehyde
• CAS No.: 914349-19-2
• Molecular Formula: C11H7 Cl N2 O
• Molecular Weight: 218.642
• Hs Code.: 2933990090
• Mol file: 914349-19-2.mol

Synonyms:4-(6-chloropyridazin-3-yl)-benzaldehyde;RW2335;

Chemical Property of 4-(6-Chloropyridazin-3-yl)benzaldehyde

Chemical Property:

• Vapor Pressure: 4.59E-08mmHg at 25°C
• Boiling Point: 443.6oC at 760 mmHg
• Flash Point: 222.1oC
• PSA: 42.85000
• Density: 1.326g/cm3
• LogP: 2.60950
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(6-Chloropyridazin-3-yl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(6-Chloropyridazin-3-yl)benzaldehyde

There total 1 articles about 4-(6-Chloropyridazin-3-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

3,6-dichlorpyridazine (141-30-0) + 4-formylphenylboronic acid, (87199-17-5) → 4-(6-chloropyridazin-3-yl)benzaldehyde (914349-19-2)

Guidance literature:

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In 1,4-dioxane; water; at 90 ℃;

Reference yield: 98.0%

4-(6-chloropyridazin-3-yl)benzaldehyde (914349-19-2) → (4-(6-chloropyridazin-3-yl)phenyl)methanol

Guidance literature:

With sodium tetrahydroborate; In methanol; dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield: 65.0%

4-(6-chloropyridazin-3-yl)benzaldehyde (914349-19-2) + 4-(diphenylamino)phenyl boronic acid (201802-67-7) → 4-(6-(4-(diphenylamino)phenyl)pyridazin-3-yl)benzaldehyde

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; for 16h; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.7b01442

upstream raw materials:

3,6-dichlorpyridazine

4-formylphenylboronic acid,

Downstream raw materials:

2-(4-(6-chloropyridazin-3-yl)phenyl)-6-methoxybenzo[d]thiazole

Refernces

• 1、 Klikar, Milan,Le Poul, Pascal,Ru?i?ka, Ale?,Pytela, Old?ich,Barsella, Alberto,Dorkenoo, Kokou D.,Robin-Le Guen, Fran?oise,Bure?, Filip,Achelle, Sylvain. "Dipolar NLO Chromophores Bearing Diazine Rings as π-Conjugated Linkers". . p. 9435 - 9451. Retrieved 2017/09/23.