ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid

Base Information

• Chemical Name: ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid
• CAS No.: 1422469-70-2
• Molecular Formula: C₄H₆O₄*C₂₇H₂₆N₆O₃
• Molecular Weight: 600.631
• Mol file: 1422469-70-2.mol

Synonyms:

Chemical Property of ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid

There total 3 articles about ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate (212322-56-0) → ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid (1422469-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 24 h / 25 °C

1.2: 12 h / 70 °C

2.1: ethyl acetate

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethyl acetate;

DOI:10.3987/COM-13-12746

Reference yield:

(4-cyanophenyl)glycine (42288-26-6) → ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid (1422469-70-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 24 h / 25 °C

1.2: 12 h / 70 °C

2.1: ethyl acetate

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethyl acetate;

DOI:10.3987/COM-13-12746

Reference yield:

succinic acid (110-15-6) + 3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester (211915-84-3) → ethyl 3-[[2-[(4-cyanophenylamino)methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate succinic acid (1422469-70-2)

Guidance literature:

In ethyl acetate;

DOI:10.3987/COM-13-12746

upstream raw materials:

succinic acid

3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester

ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate

(4-cyanophenyl)glycine

Downstream raw materials:

ethyl 2-[[4-(aminoiminomethyl)phenylamino]methyl]-1-methyl-1H-benzimidazole-5-carboxylate hydrochloride

ethyl 2-[[4-[(n-hexyloxycarbonyl)aminoiminomethyl]phenylamino]methyl]-1-methyl-1H-benzimidazole-5-carboxylate

ethyl 3-[[2-[[ethoxy(imino)methylphenylamino]methyl]-1-methyl-1H-benzimidazole-5-carbonyl]pyridin-2-yl-amino]propionate hydrochloride

C₂₁H₂₄N₄O₃*ClH