4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline

Base Information

• Chemical Name: 4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline
• CAS No.: 20440-94-2
• Molecular Formula: C20H19NO2
• Molecular Weight: 305.376
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID30441568
• Nikkaji Number: J1.807.918F
• Wikidata: Q72468653
• Mol file: 20440-94-2.mol

Synonyms:4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline;20440-94-2;4,4'-Dimethoxytriphenylamine;Benzenamine, 4-methoxy-N-(4-methoxyphenyl)-N-phenyl-;Bis(4-methoxyphenyl)phenylamine;C20H19NO2;SCHEMBL578164;4,4'-Dimethoxy Triphenylamine;N,N-di(4-methoxyphenyl)aniline;N,N-bis(4-methoxyphenyl)aniline;DTXSID30441568;MFCD16659084;DS-14679;CS-0150381;FT-0748239;C73851;A879618

Chemical Property of 4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline

Chemical Property:

• Melting Point: 103 °C
• Boiling Point: 453.4±30.0 °C(Predicted)
• PKA: -1.74±0.50(Predicted)
• PSA: 21.70000
• Density: 1.136
• LogP: 5.17360
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 5.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 305.141578849
• Heavy Atom Count: 23
• Complexity: 303

Purity/Quality:

99.50% ^*data from raw suppliers

4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=C(C=C3)OC

Technology Process of 4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline

There total 15 articles about 4-Methoxy-N-(4-methoxyphenyl)-N-phenylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-bromo-4-methoxy-benzene (104-92-7) + aniline (62-53-3) → N,N-bis(4-methoxyphenyl)aniline (20440-94-2)

Guidance literature:

With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate; In neat (no solvent); at 110 ℃; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1002/ejoc.201501616

Reference yield: 95.0%

para-iodoanisole (696-62-8) + aniline (62-53-3) → N,N-bis(4-methoxyphenyl)aniline (20440-94-2)

Guidance literature:

With [2,2]bipyridinyl; potassium tert-butylate; copper(l) iodide; In toluene; at 115 ℃; for 3.5h;

DOI:10.1016/S0040-4039(02)01708-2

Reference yield: 92.0%

bromobenzene (108-86-1,52753-63-6) + bis(4-methoxyphenyl)amine (101-70-2) → N,N-bis(4-methoxyphenyl)aniline (20440-94-2)

Guidance literature:

With tri-tert-butyl phosphine; potassium tert-butylate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.inorgchem.6b02446

upstream raw materials:

para-iodoanisole

aniline

1-bromo-4-methoxy-benzene

4-chloromethoxybenzene

Downstream raw materials:

(E,E)-1,4-bis[4-{bis(4-methoxyphenyl)amino}styryl]benzene

Refernces

• 1、 Gao, Yuting,Zhang, Jiaxin,He, Zhenyan,Luo, Liang,Yan, Chunjie. "Platinum-based photosensitizer with near-infrared aggregation-induced emission for synergistic photodynamic-chemo theranostics". . . Retrieved 2021/02/27.
• 2、 Fakis, Mihalis,Georgiou, Dimitris,Gyepes, Róbert,Hrobárik, Peter,Nociarová, Jela,Osusky, Patrik,Polyzos, Ioannis,Smolí?ek, Maro?. "Oxidative C-H Homocoupling of Push-Pull Benzothiazoles: An Atom-Economical Route to Highly Emissive Quadrupolar Arylamine-Functionalized 2,2′-Bibenzothiazoles with Enhanced Two-Photon Absorption". supporting information. p. 5512 - 5517. Retrieved 2021/07/31.