4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone

Base Information

• Chemical Name: 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone
• CAS No.: 83133-17-9
• Molecular Formula: C19H18O8
• Molecular Weight: 374.347
• Hs Code.: 2932999099
• Mol file: 83133-17-9.mol

Synonyms:5,4'-dihydroxy-3,3',7-trimethoxyflavone;quercetin 3,3',7-trimethyl ether;4',5-Dihydroxy-3,3',7-trimethoxyflavone;5,4'-dihydroxy-6,7,3',5'-tetramethoxyflavone;5,4'-dihydroxy-3,7,3'-trimethoxyflavone;Pachypodol;5,4'-dihydroxy-6,7,3',5'-teramethoxyflavone;Quercetin 3,7,3'-trimethyl ether;4',5-dihydroxy-3',5',6,7-tetramethoxyflavone;4',5-dihydroxyoxy-3',5',6,7-tetramethoxyflavone;

Chemical Property of 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone

Chemical Property:

• PSA: 107.59000
• LogP: 2.90560
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4',5-Dihydroxy-3',5',6,7-Tetramethoxyflavone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone

There total 11 articles about 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4'-hydroxy-3',5,5',6,7-pentamethoxyflavone (93124-90-4) → 4',5-dihydroxyoxy-3',5',6,7-tetramethoxyflavone (83133-17-9)

Guidance literature:

4'-hydroxy-3',5,5',6,7-pentamethoxyflavone; With aluminum (III) chloride; In acetonitrile; for 1h; Heating;

With hydrogenchloride; In water; for 1h; regioselective reaction; Reflux;

DOI:10.1080/14786419.2021.1961136

Reference yield:

6-hydroxy-2,3,4-trimethoxyacetophenone (22248-14-2) → 4',5-dihydroxyoxy-3',5',6,7-tetramethoxyflavone (83133-17-9)

Guidance literature:

Multi-step reaction with 5 steps

1: CF₃COOH / benzene

2: KOH / pyridine

3: H₂SO₄ / acetic acid

4: H₂ / Pd-C / ethyl acetate

5: AlCl₃ / CH₂Cl₂

With potassium hydroxide; aluminium trichloride; sulfuric acid; hydrogen; trifluoroacetic acid; palladium on activated charcoal; In pyridine; dichloromethane; acetic acid; ethyl acetate; benzene;

Reference yield:

4'-benzyloxy-5,6,7,3',5'-pentamethoxyflavone (89354-95-0) → 4',5-dihydroxyoxy-3',5',6,7-tetramethoxyflavone (83133-17-9)

Guidance literature:

With hydrogenchloride; aluminium trichloride; Yield given. Multistep reaction; 1.) acetonitrile, reflux, 4 h, 2.) water bath, 30 min;

upstream raw materials:

4'-benzyloxy-5,6,7,3',5'-pentamethoxyflavone

4'-hydroxy-3',5,5',6,7-pentamethoxyflavone

6-hydroxy-2,3,4-trimethoxyacetophenone

4-(benzyloxy)-3,5-dimethoxybenzoic acid

Downstream raw materials:

5,4'-di-O-acetyl-6,7,3',5'-tetramethoxyflavone