Licarin A

Base Information

• Chemical Name: Licarin A
• CAS No.: 23518-30-1
• Molecular Formula: C₂₀H₂₂O₄
• Molecular Weight: 326.392
• Mol file: 23518-30-1.mol

Synonyms:Phenol,4-(2,3-dihydro-7-methoxy-3-methyl-5-propenyl-2-benzofuranyl)-2-methoxy-,(E)-trans- (8CI); Phenol,4-[(2R,3R)-2,3-dihydro-7-methoxy-3-methyl-5-(1E)-1-propenyl-2-benzofuranyl]-2-methoxy-,rel- (9CI); Phenol,4-[2,3-dihydro-7-methoxy-3-methyl-5-(1-propenyl)-2-benzofuranyl]-2-methoxy-, [2a,3b,5(E)]-; (?à)-Licarin A; (?à)-trans-Dehydrodiisoeugenol

Chemical Property of Licarin A

Chemical Property:

• Boiling Point: 452.0±45.0 °C(Predicted)
• PKA: 9.80±0.35(Predicted)
• PSA: 47.92000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 4.67970

Purity/Quality:

≥98% ^*data from raw suppliers

LicarinA ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Licarin A

There total 22 articles about Licarin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

2-methoxy-4-propenylphenol (97-54-1) → dehydrodiisoeugenol (2680-81-1,23518-29-8,23518-30-1,51020-86-1,64870-40-2,69744-09-8,72274-58-9,72274-59-0,83377-50-8,88034-58-6,127000-67-3)

Guidance literature:

With dihydrogen peroxide; horseradish peroxidase; In aq. phosphate buffer; water; acetone; at 50 ℃; for 2h; pH=5.83;

DOI:10.1016/j.cclet.2015.05.011

Reference yield: 81.0%

(E)-2-methoxy-4-(1-propenyl)phenol (5932-68-3) → (E)-1-<(2RS,3SR)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methyl-1-benzofuran-5-yl>-1-propene (2680-81-1,23518-29-8,23518-30-1,51020-86-1,64870-40-2,69744-09-8,72274-58-9,72274-59-0,83377-50-8,88034-58-6,127000-67-3)

Guidance literature:

With ammonium cerium (IV) nitrate; In tetrahydrofuran; at 0 ℃; for 1.5h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1016/j.tet.2012.11.006

Reference yield: 40.0%

(E)-2-methoxy-4-(1-propenyl)phenol (5932-68-3) → (E)-1-<(2RS,3SR)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3-methyl-1-benzofuran-5-yl>-1-propene (2680-81-1,23518-29-8,23518-30-1,51020-86-1,64870-40-2,69744-09-8,72274-58-9,72274-59-0,83377-50-8,88034-58-6,127000-67-3) + threo-1-(4-hydroxy-3-methoxyphenyl)-1-methoxy-2-<2-methoxy-4-(1-propenyl)phenoxy>propane + erythro-1-(4-hydroxy-3-methoxyphenyl)-1-methoxy-2-<2-methoxy-4-(1-propenyl)phenoxy>propane + 4-(syn-1,2-dimethoxypropyl)-2-methoxyphenol + 4-(anti-1,2-dimethoxypropyl)-2-methoxyphenol

Guidance literature:

With lithium perchlorate; In methanol; at 20 ℃; Electrolysis;

DOI:10.1002/anie.201200878

upstream raw materials:

(E)-2-methoxy-4-(1-propenyl)phenol

methanol

2-methoxy-4-propenylphenol

acetic anhydride

Downstream raw materials:

5-formylvanillin

3-methoxy-4-hydroxybenzoic acid

3-carboxy-4-hydroxy-5-methoxybenzaldehyde

vanillin