methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate

Base Information

Chemical Name:methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate
CAS No.:1383790-81-5
Molecular Formula:C₃₃H₃₅NO₄
Molecular Weight:509.645
Hs Code.:

Synonyms:

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Chemical Property of methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate

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Technology Process of methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate

There total 9 articles about methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: C₃₄H₃₇NO₄

: 1383790-81-5
methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate

Guidance literature:: at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.04.106

Reference yield:

: 2-benzyl-1-bromo-4-methoxybenzene

: 1383790-81-5
methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate; tris-(o-tolyl)phosphine / dichloromethane; water / 1 h / 115 °C / Inert atmosphere

3.2: 115 °C / Inert atmosphere

4.1: caesium carbonate / acetone / 80 °C / Inert atmosphere

4.2: 80 °C / Inert atmosphere

5.1: 20 °C / Inert atmosphere

With dichlorobis(tri-O-tolylphosphine)palladium; boron tribromide; sodium hydride; sodium carbonate; caesium carbonate; tris-(o-tolyl)phosphine; In tetrahydrofuran; dichloromethane; water; acetone; 3.2: Suzuki-Miyaura coupling / 4.2: Williamson synthesis;
DOI:10.1016/j.tet.2012.04.106

Reference yield:

: 1383790-49-5
3-benzyl-4-bromophenol

: 1383790-81-5
methyl 2-((2,2'-dibenzyl-4'-(2-(dimethylamino)ethoxy)-[1,1'-biphenyl]-4-yl)oxy)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

2.1: dichlorobis(tri-O-tolylphosphine)palladium; sodium carbonate; tris-(o-tolyl)phosphine / dichloromethane; water / 1 h / 115 °C / Inert atmosphere

2.2: 115 °C / Inert atmosphere

3.1: caesium carbonate / acetone / 80 °C / Inert atmosphere

3.2: 80 °C / Inert atmosphere

4.1: 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichlorobis(tri-O-tolylphosphine)palladium; potassium acetate; sodium carbonate; caesium carbonate; tris-(o-tolyl)phosphine; In 1,4-dioxane; dichloromethane; water; acetone; 2.2: Suzuki-Miyaura coupling / 3.2: Williamson synthesis;
DOI:10.1016/j.tet.2012.04.106