2-(AMINOMETHYL)BENZOIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 2-(AMINOMETHYL)BENZOIC ACID HYDROCHLORIDE
• CAS No.: 10017-39-7
• Molecular Formula: C8H9NO2.ClH
• Molecular Weight: 187.626
• Hs Code.: 2922499990
• Mol file: 10017-39-7.mol

Synonyms:Benzoic acid, 2-(aminomethyl)-, hydrochloride (9CI);o-Toluic acid, α-amino-, hydrochloride (6CI,7CI,8CI);2-(Aminomethyl)benzoic acid hydrochloride;

Chemical Property of 2-(AMINOMETHYL)BENZOIC ACID HYDROCHLORIDE

Chemical Property:

• Melting Point: 219-225°C
• PSA: 63.32000
• LogP: 2.34580
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Aminomethyl)benzoic acid hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-37/38-41-50
• Safety Statements: 26-36/39-61

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(AMINOMETHYL)BENZOIC ACID HYDROCHLORIDE

There total 12 articles about 2-(AMINOMETHYL)BENZOIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoic acid (53663-18-6) → (2-benzylamino)carboxylic acid hydrochloride (10017-39-7)

Guidance literature:

With hydrazine; In ethanol; N,N-dimethyl-formamide; at 75 ℃; for 2h;

DOI:10.1080/00397919808004516

Reference yield: 85.0%

oxisoindole (480-91-1) → (2-benzylamino)carboxylic acid hydrochloride (10017-39-7)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1016/j.bmcl.2007.10.060

Reference yield: 85.0%

2-acetyl-2,3-dihydro-1H-isoindol-1-one (3006-64-2) → (2-benzylamino)carboxylic acid hydrochloride (10017-39-7)

Guidance literature:

With hydrogenchloride; In water monomer; Schlenk technique; Inert atmosphere; Reflux;

DOI:10.1002/chem.201600107

upstream raw materials:

2-cyanobenzoic acid

2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]benzoic acid

oxisoindole

phthalimide

Downstream raw materials:

2-(((fluorenylmethoxcarbonyl)amino)methyl)benzoic acid

Refernces

• 1、 Hu, Xiao-Qiang,Liu, Zi-Kui,Hou, Ye-Xing,Xu, Ji-Hang,Gao, Yang. "Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis". . p. 6332 - 6336. Retrieved 2021.
• 2、 Gao, Yuhan,Huang, Zhiliang,Lei, Aiwen,Yi, Hong,Yu, Mingming,Zhang, Lin,Zhang, Yingjie,Zhang, Yiyan. "Electrochemical-induced benzyl C-H amination towards the synthesis of isoindolinones via aroyloxy radical-mediated C-H activation". . p. 1445 - 1450. Retrieved 2022/03/08.