3006-64-2Relevant academic research and scientific papers
Cu/Fe Catalyzed Intermolecular Oxidative Amination of Benzylic C-H Bonds
Liu, Cong,Zhang, Qi,Li, Hongbo,Guo, Shuangxi,Xiao, Bin,Deng, Wei,Liu, Lei,He, Wei
supporting information, p. 6208 - 6212 (2016/05/09)
We report a Cu/Fe co-catalyzed Ritter-type C-H activation/amination reaction that allows efficient and selective intermolecular functionalization of benzylic C-H bonds. This new reaction is featured by simple reaction conditions, readily available reagents and general substrate scope, allowing facile synthesis of biologically interesting nitrogen containing heterocycles. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis. With a little help: A Ritter-type intermolecular amination of benzylic C-H bonds with acetonitrile, co-catalyzed by CuII/FeIII is reported. A wide array of biologically interesting nitrogen containing heterocycles was prepared from 2-alkyl benzoic acids and heteroaromatic carboxylic acids under operationally simple conditions. The Cu and Fe salts were found to play distinct roles in this cooperative catalysis.
PHOTOREDUCTION DE LA BENZOPHENONE PAR DES PHTALIMIDINES ET DES DIHYDRO ISOQUINOLONES. ETUDE CHIMIQUE ET PAR RMN PNIC
Gramain, J. C.,Simonet, N.,Vermeersch, G.,Febvay-Garot, N.,Caplain, S.,Lablache-Combier, A.
, p. 539 - 550 (2007/10/02)
Benzophenone is photoreduced by phtalimidines and dihydro isoquinolones.The hydrogen atom α to the nitrogen atom is abstracted and radical coupling leads to adducts.CIDNP studies of these adducts show inversion of polarisation for the adduct on the N-alkyl chain when the nitrogen is bound to a benzylic methylene.This inversion is explained by considering that the radical on the N-alkyl chain derives from the radical on the ring.
