5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde

Base Information

• Chemical Name: 5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde
• CAS No.: 204452-93-7
• Molecular Formula: C9H10N2O
• Molecular Weight: 162.18800
• Hs Code.: 2933990090
• Mol file: 204452-93-7.mol

Synonyms:5,6,7,8-tetrahydro[1,8]naphthyridine-2-aldehyde;A4449;5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carboxaldehyde;5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carbaIdehyde;5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carbaldehyde;

Chemical Property of 5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 63.5-64 °C
• Boiling Point: 326.091oC at 760 mmHg
• PKA: 10.31±0.40(Predicted)
• Flash Point: 151.015oC
• PSA: 41.99000
• Density: 1.182g/cm3
• LogP: 1.39020

Purity/Quality:

97% ^*data from raw suppliers

5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde

There total 3 articles about 5,6,7,8-tetrahydro-1,8-naphthyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

3(S)-(6-methoxypyridin-3-yl)-3-alanine tert-butyl ester p-toluenesulfonic acid (204452-91-5) → 5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carboxaldehyde (204452-93-7)

Guidance literature:

With hydrogenchloride; In water; at 85 ℃; for 2.5h;

Reference yield:

2-Aminonicotinaldehyde (7521-41-7) → 5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carboxaldehyde (204452-93-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / NaOH / ethanol; H₂O / 1 h / 20 °C

2: 92 percent / H₂ / PtO₂ / ethanol / 18 h / 20 °C / 760 Torr

3: aq. HCl / 2.5 h / 85 °C

With hydrogenchloride; sodium hydroxide; hydrogen; platinum(IV) oxide; In ethanol; water; 1: Friedlaender reaction;

DOI:10.1021/jo030297u

Reference yield:

2-(dimethoxymethyl)-1,8-naphthyridine (204452-90-4) → 5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carboxaldehyde (204452-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂ / PtO₂ / ethanol / 18 h / 20 °C / 760 Torr

2: aq. HCl / 2.5 h / 85 °C

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol;

DOI:10.1021/jo030297u

upstream raw materials:

3(S)-(6-methoxypyridin-3-yl)-3-alanine tert-butyl ester p-toluenesulfonic acid

2-Aminonicotinaldehyde

2-(dimethoxymethyl)-1,8-naphthyridine

Downstream raw materials:

(S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid

3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propane-1-amine

(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)methanol

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