5-(Chloromethyl)quinoline

Base Information

Chemical Name:5-(Chloromethyl)quinoline
CAS No.:110333-07-8
Molecular Formula:C10H8ClN
Molecular Weight:177.63
Hs Code.:2933499090
DSSTox Substance ID:DTXSID70562781
Nikkaji Number:J345.906C
Wikidata:Q82447057
Mol file:110333-07-8.mol

Synonyms:5-(Chloromethyl)quinoline;110333-07-8;5-Chloromethylquinoline;Quinoline, 5-(chloromethyl)-;SCHEMBL6629717;DTXSID70562781;AKOS012169889;SB68257;CS-0269016;EN300-173708

Suppliers and Price of 5-(Chloromethyl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-(Chloromethyl)quinoline
50mg
$ 175.00

Crysdot
5-(Chloromethyl)quinoline 95+%
1g
$ 987.00

Chemenu
5-(chloromethyl)quinoline 95%
1g
$ 931.00

American Custom Chemicals Corporation
5-(CHLOROMETHYL)QUINOLINE 95.00%
5MG
$ 503.40

AccelPharmtech
5-(chloromethyl)-Quinoline 97.00%
25G
$ 6000.00

AccelPharmtech
5-(chloromethyl)-Quinoline 97.00%
5G
$ 3230.00

AccelPharmtech
5-(chloromethyl)-Quinoline 97.00%
1G
$ 1890.00

Total 12 raw suppliers

Chemical Property of 5-(Chloromethyl)quinoline

Chemical Property:

Melting Point:90-90.5 °C
Boiling Point:310.6±17.0 °C(Predicted)
PKA:4.55±0.12(Predicted)
PSA：12.89000
Density:1.229±0.06 g/cm3(Predicted)
LogP:2.97360
Storage Temp.:2-8°C
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:177.0345270
Heavy Atom Count:12
Complexity:149

Purity/Quality:

97% ^*data from raw suppliers

5-(Chloromethyl)quinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C2C=CC=NC2=C1)CCl

Technology Process of 5-(Chloromethyl)quinoline

There total 3 articles about 5-(Chloromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.62%

: 16178-42-0
quinolin-5-ylmethanol

: 110333-07-8
5-(chloromethyl)quinoline

Guidance literature:: With thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 110333-07-8
5-(chloromethyl)quinoline

Guidance literature:: With thionyl chloride;
DOI:10.1021/ja01609a087

Reference yield:

: 22934-41-4
quinoline-5-carbaldehyde

: 110333-07-8
5-(chloromethyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 8 h / 0 - 20 °C

2: triethylamine; methanesulfonyl chloride / dichloromethane / 3 h / 0 °C

With sodium tetrahydroborate; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane;
DOI:10.1039/c5md00242g