22934-41-4

Usage

Uses

Quinoline-5-carboxaldehyde is used as a precursor in the preparation of pharmaceuticals.

InChI:InChI=1/C10H7NO/c12-7-8-3-1-5-10-9(8)4-2-6-11-10/h1-7H

Upstream product

• 7661-55-4 5-methylquinoline 
• 4964-71-0 5-bromoquinoline 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 16178-42-0 quinolin-5-ylmethanol 
• 555155-04-9 2-(quinolin-5-yl)acetonitrile 
• 883557-49-1 {5-[2-((E)-2-Quinolin-5-yl-vinyl)-pyridin-3-yl]-[1,3,4]oxadiazol-2-yl}-(3-trifluoromethyl-phenyl)-amine 
• 1022155-23-2 9-(2-methoxyphenyl)-8-oxo-2-(quinolin-5-yl)-8,9-dihydro-7H-purine-6-carboxamide 
• 110333-07-8 5-(chloromethyl)quinoline 
• 1581755-47-6 N-(3-fluorobenzyl)-1-(1-(quinolin-5-yl)ethyl)piperidine-4-carboxamide 
• 880782-86-5 1-(quinolin-5-yl)ethan-1-ol 
• 1424395-17-4 C₃₀H₂₄Cl₂N₄O₅ 
• 1424395-06-1 C₃₁H₂₆Cl₂N₄O₅ 
• 1207549-21-0 C₂₁H₂₀BrN₃O₄ 
• 103854-56-4 1-(quinolin-5-yl)ethan-1-one 
• 1198319-65-1 (S)-6-benzyl-4-(cyclopropanecarbonyl)-2-(2-(1-(quinolin-5-ylmethyl)piperidin-4-yl)ethyl)-4,5,6,7-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-one 
• 98421-29-5 5-(2-benzamidoethyl)quinoline 
• 98421-32-0 5-(2-benzamidoethyl)carbostyril 

Relevant academic research and scientific papers

MALT1 MODULATORS AND USES THEREOF

Provided herein are compounds, compositions, and methods useful for modulating MALT1 and for treating related diseases, disorders, and conditions.

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. Benzoxazepines were recently identified as a novel class of MTAs. These anticancer agents were thoroughly characterized for their antitumor activity, although, their exact mechanism of action remained elusive. Combining chemical, biochemical, cellular, bioinformatics and structural efforts we developed improved pyrrolonaphthoxazepines antitumor agents and their mode of action at the molecular level was elucidated. Compound 6j, one of the most potent analogues, was confirmed by X-ray as a colchicine-site MTA. A comprehensive structural investigation was performed for a complete elucidation of the structure-activity relationships. Selected pyrrolonaphthoxazepines were evaluated for their effects on cell cycle, apoptosis and differentiation in a variety of cancer cells, including multidrug resistant cell lines. Our results define compound 6j as a potentially useful optimized hit for the development of effective compounds for treating drug-resistant tumors.

N-aryl(thio)anthranilic acid amide derivatives, their preparation and their use as VEGF receptor tyrosine kinase inhibitors

Described are compounds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10-(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of